Association of cytomegalovirus infection with hemorheology, endothelin level and prognosis of elderly patients with coronary heart disease

ABSTRACT

OBJECTIVE: To explore the association of cytomegalovirus(CMV) infection with hemorheology, endothelin level and prognosis of elderly patients with coronary heart disease. METHODS: A total of 86 elderly patients with coronary heart disease who had CMV infection and were treated in the Second Affiliated Hospital of Henan University of Science and Technology from Oct 2017 to Jun 2019 were assigned as the infection group, and 71 patients without CMV infection were chosen as the no infection group. The hemorheological indexes, endothelin level and incidence of adverse cardiovascular events were compared between the two groups, and the relationship between CMV-DNA load and hemorheological indexes, endothelin level was observed. RESULTS: The high shear viscosity, low shear viscosity, plasma viscosity, Hematocrit and endothelin level of the infection group were respectively(6.89+or-0.95)mPa.s,(11.12+or-1.20)mPa.s,(2.31+or-0.45) mPa.s, (53.54+or-4.97)% and(89.34+or-9.63)pg/ml, significantly higher than those of the no infection group(P<0.05). The endothelin level of the patients with CMV-DNA load no less than 1x10~3copies/ml was significantly higher than that of the patients with CMV-DNA load less than 1x10~3 copies/ml(P<0.05). The incidence of adverse cardiovascular events of the infection group was 12.79%, significantly higher than that of the no infection group(P<0.05). CONCLUSION: The CMV infection may raise the levels of hemorheological indexes and endothelin of the elderly patients with coronary heart disease and lead to the increase of incidence of adverse cardiovascular events.