Omicron and Delta variant spike protein mutations comparison and their interaction with ACE2 receptor

ABSTRACT

The current outbreak of coronavirus-associated disease characterized as coronavirus disease 19 (COVID-19) marked its existence in late 2019. Since then, it has been a concern for human health and safety. Coronaviruses (CoVs) are known to cause a wide range of diseases;out of which common cold and pneumonia occur in human beings. In this review, we elaborate on the basic characteristics, structure, variants mutations and the pathological attributes of SARS-CoV 2. We also discuss the interaction of the viral proteins with the host cell receptor known as the ACE2 receptor and various therapeutics for the treatment of disease.