Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis.
Alzheimers Dement
; 18(11): 2167-2175, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-2172368
ABSTRACT
INTRODUCTION:
Several investigations have argued for a strong relationship between neuroinflammation and amyloid metabolism but it is still unclear whether inflammation exerts a pro-amyloidogenic effect, amplifies the neurotoxic effect of amyloid, or is protective.METHODS:
Forty-two patients with acute encephalitis (ENC) and 18 controls underwent an extended cerebrospinal fluid (CSF) panel of inflammatory, amyloid (Aß40, 42, and 38, sAPP-α, sAPP-ß), glial, and neuronal biomarkers. Linear and non-linear correlations between CSF biomarkers were evaluated studying conditional independence relationships.RESULTS:
CSF levels of inflammatory cytokines and neuronal/glial markers were higher in ENC compared to controls, whereas the levels of amyloid-related markers did not differ. Inflammatory markers were not associated with amyloid markers but exhibited a correlation with glial and neuronal markers in conditional independence analysis.DISCUSSION:
By an extensive CSF biomarkers analysis, this study showed that an acute neuroinflammation state, which is associated with glial activation and neuronal damage, does not influence amyloid homeostasis.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Encephalitis
/
Alzheimer Disease
/
Amyloidosis
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Alzheimers Dement
Year:
2022
Document Type:
Article
Affiliation country:
Alz.12554
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