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Unlocking G-Quadruplexes as Targets and Tools against COVID-19.
Qin, Geng; Zhao, Chuanqi; Yang, Jie; Wang, Zhao; Ren, Jinsong; Qu, Xiaogang.
  • Qin G; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun, Jilin 130022 China.
  • Zhao C; University of Science and Technology of China Hefei Anhui 230026 China.
  • Yang J; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun, Jilin 130022 China.
  • Wang Z; University of Science and Technology of China Hefei Anhui 230026 China.
  • Ren J; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun, Jilin 130022 China.
  • Qu X; University of Science and Technology of China Hefei Anhui 230026 China.
Chin J Chem ; 2022 Dec 30.
Article in English | MEDLINE | ID: covidwho-2230294
ABSTRACT
The applicability of G-quadruplexes (G4s) as antiviral targets, therapeutic agents and diagnostic tools for coronavirus disease 2019 (COVID-19) is currently being evaluated, which has drawn the extensive attention of the scientific community. During the COVID-19 pandemic, research in this field is rapidly accumulating. In this review, we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets, therapeutic agents and diagnostic tools for COVID-19, particularly using G4 ligands. Finally, strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article