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Efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for COVID-19: A rapid review and meta-analysis.
Amani, Behnam; Amani, Bahman.
  • Amani B; Department of Epidemiology, School of Health, Ilam University of Medical Sciences, Ilam, Iran.
  • Amani B; Department of Epidemiology, School of Health, Ilam University of Medical Sciences, Ilam, Iran.
J Med Virol ; 95(2): e28441, 2023 02.
Article in English | MEDLINE | ID: covidwho-2227447
ABSTRACT
This study aimed to examine the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for coronavirus disease 2019 (COVID-19). PubMed, Cochrane Library, Web of Science, medRxiv, and Google Scholar were searched to identify the relevant evidence up to November 10, 2022. The reference lists of key studies were also scanned to find additional records. The quality of the studies was evaluated using the Cochrane tools for assessing the risk of bias. The Comprehensive Meta-Analysis software version 3.0 was employed for data analysis. Twenty-three studies involving 314 353 patients were included in the analysis. The findings of the meta-analysis showed a significant difference between the Paxlovid and no-Paxlovid groups in terms of mortality rate (odds ratio [OR] = 0.25; 95% confidence interval [CI] 0.14-0.45), hospitalization rate (OR = 0.40; 95% CI 0.24-0.69), polymerase chain reaction negative conversion time (mean difference [MD] = -2.46; 95% CI -4.31 to -0.61), and hospitalization or death rate (OR = 0.17; 95% CI 0.06-0.46). However, no significant difference was observed between the two groups in terms of COVID-19 rebound (OR = 0.84; 95% CI 0.67-1.04), emergency department visit (OR = 0.75; 95% CI 0.45-1.24), intensive care unit admission (OR = 0.37; 95% CI 0.13-1.01), and adverse events (OR = 2.20; 95% CI 0.42-11.47). The results of the present study support the efficacy and safety of Paxlovid in the treatment of patients with COVID-19. Further research is needed to investigate the COVID-19 rebound after Paxlovid treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ritonavir / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28441

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ritonavir / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28441