Your browser doesn't support javascript.
Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID-19, and radiotherapy.
Taysi, Seyithan; Algburi, Firas Shawqi; Taysi, Muhammed Enes; Caglayan, Cuneyt.
  • Taysi S; Department of Medical Biochemistry, Medical School, Gaziantep University, Gaziantep, Turkey.
  • Algburi FS; Department of Medical Biochemistry, Medical School, Gaziantep University, Gaziantep, Turkey.
  • Taysi ME; Department of Biology, College of Science, Tikrit University, Tikrit, Iraq.
  • Caglayan C; College of Dentistry, Al-Kitab University, Altun Kupri, Iraq.
Phytother Res ; 37(3): 1115-1135, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2283713
ABSTRACT
Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti-cancer, anti-inflammatory, antioxidant, antibacterial and anti-fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS-CoV-2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti-proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID-19).
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Phenylethyl Alcohol / COVID-19 Type of study: Risk_factors_studies Topics: Traditional medicine Limits: Humans Language: English Journal: Phytother Res Journal subject: Complementary Therapies Year: 2023 Document Type: Article Affiliation country: Ptr.7707

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Phenylethyl Alcohol / COVID-19 Type of study: Risk_factors_studies Topics: Traditional medicine Limits: Humans Language: English Journal: Phytother Res Journal subject: Complementary Therapies Year: 2023 Document Type: Article Affiliation country: Ptr.7707