Tissue-resident immunity in the lung: a first-line defense at the environmental interface.
Semin Immunopathol
; 44(6): 827-854, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-2174069
ABSTRACT
The lung is a vital organ that incessantly faces external environmental challenges. Its homeostasis and unimpeded vital function are ensured by the respiratory epithelium working hand in hand with an intricate fine-tuned tissue-resident immune cell network. Lung tissue-resident immune cells span across the innate and adaptive immunity and protect from infectious agents but can also prove to be pathogenic if dysregulated. Here, we review the innate and adaptive immune cell subtypes comprising lung-resident immunity and discuss their ontogeny and role in distinct respiratory diseases. An improved understanding of the role of lung-resident immunity and how its function is dysregulated under pathological conditions can shed light on the pathogenesis of respiratory diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunity, Innate
/
Lung
Limits:
Humans
Language:
English
Journal:
Semin Immunopathol
Journal subject:
Allergy and Immunology
/
Pathology
Year:
2022
Document Type:
Article
Affiliation country:
S00281-022-00964-2
Similar
MEDLINE
...
LILACS
LIS