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A multicentre study on the incidence of respiratory viruses in children with community-acquired pneumonia requiring hospitalization in the setting of the zero-COVID policy in China.
Feng, Ziheng; Xu, Baoping; Zhong, Lili; Chen, Jing; Deng, Jikui; Luo, Zhengxiu; Cao, Lingfeng; Tang, Yu; Li, Changchong; Jin, Rong; Deng, Li; Shang, Yunxiao; Wu, Ying; Zhao, Hongwei; Feng, Qianyu; Chen, Xiangpeng; Xu, Lili; Xie, Zhengde.
  • Feng Z; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institut
  • Xu B; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, 2019RU016, China.
  • Zhong L; Department of Respiratory Diseases I, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.
  • Chen J; Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
  • Deng J; Shenyang Children's Hospital, Shenyang, China.
  • Luo Z; Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
  • Cao L; Department of Respiratory Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Tang Y; Department of Clinical Laboratory, Children's Hospital of Fudan University, Shanghai, China.
  • Li C; Department of Respiratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
  • Jin R; The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
  • Deng L; Guiyang Women and Children Healthcare Hospital, Guiyang, China.
  • Shang Y; Guangzhou Women and Children's Medical Center, Guangzhou, China.
  • Wu Y; Shengjing Hospital of China Medical University, Shenyang, China.
  • Zhao H; Department of Clinical Laboratory Medicine, National Children's Medical Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
  • Feng Q; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institut
  • Chen X; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, 2019RU016, China.
  • Xu L; Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institut
  • Xie Z; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, 2019RU016, China.
Arch Virol ; 168(2): 64, 2023 Jan 13.
Article in English | MEDLINE | ID: covidwho-2174219
ABSTRACT

BACKGROUND:

Stringent nonpharmaceutical interventions (NPIs) have been implemented worldwide to combat the COVID-19 pandemic, and the circulation and seasonality of common respiratory viruses have subsequently changed. There have been few multicentre studies or comparisons of the prevalence of respiratory viruses accounting for community-acquired pneumonia (CAP) in hospitalized children between the pre-COVID period and the period after community and school reopening in the setting of the zero-COVID policy.

METHODS:

We included 1543 children with CAP who required hospitalization from November 1, 2020 to April 30, 2021 (period 1), and 629 children with the same conditions from November 1, 2018, to April 30, 2019 (period 2), in our study. All respiratory samples from these patients were screened for six respiratory viruses (respiratory syncytial virus [RSV], adenovirus [ADV], influenza A virus [Flu A], influenza B virus [Flu B], parainfluenza virus type 1 [PIV1], and parainfluenza virus type 3 [PIV3]) using a multiplex real-time PCR assay. RESULTS AND

CONCLUSIONS:

The median ages of the enrolled patients at the time of diagnosis were 1.5 years and 1.0 years for period 1 and period 2, respectively. In period 1, viral pathogens were detected in 50.3% (776/1543) of the enrolled patients. The most frequently identified viral pathogen was RSV (35.9%, 554/1543), followed by PIV3 (9.6%, 148/1543), PIV1 (3.6%, 56/1543), ADV (3.4%, 52/1543), Flu A (1.0%, 16/1543), and Flu B (0.8%, 13/1543). The total detection rates of these six viruses in the peak season of CAP were at the pre-COVID level. The prevalence of Flu A decreased dramatically, and circulation activity was low compared to pre-COVID levels, while the incidence of PIV3 increased significantly. There were no significant differences in the detection rates of RSV, ADV, Flu B, and PIV1 between the two periods. Our results showed that respiratory viruses accounted for CAP in hospitalized children at pre-COVID levels as communities and schools reopened within the zero-COVID policy, although the prevalence aetiology spectrum varied.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Adenoviridae Infections / COVID-19 Type of study: Etiology study / Observational study Limits: Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Adenoviridae Infections / COVID-19 Type of study: Etiology study / Observational study Limits: Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: Arch Virol Year: 2023 Document Type: Article