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High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load.
Ríos, Esther; Medrano, Sara; Alvarez, Mar; Valderrama, María José; Vallejo, Luis; Delgado-Iribarren, Alberto; Culebras, Esther.
  • Ríos E; Department of Medicine, Facultad de Medicina, Universidad Complutense Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain. erios02@ucm.es.
  • Medrano S; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain. erios02@ucm.es.
  • Alvarez M; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
  • Valderrama MJ; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
  • Vallejo L; Department of Genetics, Physiology and Microbiology, Faculty of Biology, Universidad Complutense de Madrid, Madrid, Spain.
  • Delgado-Iribarren A; Department of Clinical Microbiology, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, IdISSC, Madrid, Spain.
  • Culebras E; Department of Medicine, Facultad de Medicina, Universidad Complutense Madrid, Plaza Ramón y Cajal S/N, Madrid, 28040, Spain.
Int Microbiol ; 2022 Dec 17.
Article in English | MEDLINE | ID: covidwho-2174403
ABSTRACT
ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies Language: English Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: S10123-022-00311-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies Language: English Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: S10123-022-00311-3