Your browser doesn't support javascript.
Critical roles of cytokine storm and bacterial infection in patients with COVID-19: therapeutic potential of mesenchymal stem cells.
Arjmand, Babak; Alavi-Moghadam, Sepideh; Sarvari, Masoumeh; Rezaei-Tavirani, Mostafa; Rezazadeh-Mafi, Ahmad; Arjmand, Rasta; Nikandish, Mohsen; Nasli-Esfahani, Ensieh; Larijani, Bagher.
  • Arjmand B; Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. barjmand@sina.tums.ac.ir.
  • Alavi-Moghadam S; Iranian Cancer Control Center (MACSA), Tehran, Iran. barjmand@sina.tums.ac.ir.
  • Sarvari M; Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Rezaei-Tavirani M; Iranian Cancer Control Center (MACSA), Tehran, Iran.
  • Rezazadeh-Mafi A; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Arjmand R; Department of Radiation Oncology, Imam Hossein Hospital, Shaheed Beheshti Medical University, Tehran, Iran.
  • Nikandish M; Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Nasli-Esfahani E; AJA Cancer Epidemiology Research and Treatment Center (AJA-CERTC), AJA University of Medical Sciences, Tehran, Iran.
  • Larijani B; Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Inflammopharmacology ; 31(1): 171-206, 2023 Feb.
Article in English | MEDLINE | ID: covidwho-2174587
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 has been a shocking disaster for healthcare systems worldwide since December 2019. This virus can affect all systems of the body and its symptoms vary from a simple upper respiratory infection to fatal complications including end-organ damage. On the other hand, the normal immune system plays a pivotal role in the recovery of infectious diseases such as COVID-19. However, occasionally, exaggerated immune system inflammation and an excessive synthesis of cytokines, known as a "cytokine storm," can deteriorate the patient's clinical condition. Secondary bacterial co-infection is another problem in COVID-19 which affects the prognosis of patients. Although there are a few studies about this complication, they suggest not using antibiotics commonly, especially broad-spectrum ones. During this pandemic, various approaches and therapeutics were introduced for treating COVID-19 patients. However, available treatments are not helpful enough, especially for complicated cases. Hence, in this era, cell therapy and regenerative medicine will create new opportunities. Therefore, the therapeutic benefits of mesenchymal stem cells, especially their antimicrobial activity, will help us understand how to treat COVID-19. Herein, mesenchymal stem cells may stop the immune system from becoming overactive in COVID-19 patients. On the other side, the stem cells' capacity for repair could encourage natural healing processes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Mesenchymal Stem Cells / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S10787-022-01132-6

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Mesenchymal Stem Cells / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S10787-022-01132-6