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Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients.
Aslan, Elif Sibel; Aydin, Hüseyin; Tekin, Yusuf Kenan; Keles, Sami; White, Kenneth N; Hekim, Nezih.
  • Aslan ES; Molecular Biology and Genetic Department, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yil Street. Protokol Road, Topkapi, Istanbul, Turkey. easlan@biruni.edu.tr.
  • Aydin H; Medical Biochemistry, Department of Basic Medical Sciences, Sivas Cumhuriyet University, Sivas, Turkey.
  • Tekin YK; Medical Biochemistry, Department of Basic Medical Sciences, Sivas Cumhuriyet University, Sivas, Turkey.
  • Keles S; Ahenk Medical Diagnosis and Research Laboratory, Yeditepe University, Istanbul, Turkey.
  • White KN; Molecular Systems for Health Research Group, School of Human Sciences, London Metropolitan University, London, UK.
  • Hekim N; Molecular Biology and Genetic Department, Faculty of Engineering and Natural Sciences, Biruni University, 10. Yil Street. Protokol Road, Topkapi, Istanbul, Turkey.
Mol Biol Rep ; 50(3): 2471-2478, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2174670
ABSTRACT

BACKGROUND:

Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with the levels of two novel biomarkers related to iron homeostasis, hephaestin and hypoxia-inducible factors-1 (HIF-1α) in the serum of patients with COVID-19 in comparison with a control group. METHODS AND

RESULTS:

Blood samples from 34 COVID-19 patients and from 43 healthy volunteers were collected and the levels of HEPH and HIF-1α were measured by ELISA and compared with levels of serum ferritin. COVID-19 patients had higher serum levels of ferritin than those levels in control group (P < 0.0001). Conversely levels of HIF-1α and HEPH in the COVID-19 group were significantly lower than those of control group (P < 0.0001 for both). An inverse correlation between hephaestin and ferritin as well as between HIF-1α and ferritin was found among all subjects (P < 0.0001), and among COVID-19 patients, but not to statistical significance.

CONCLUSION:

Levels of hephaestin and HIF-1α were found to be inversely related levels of ferritin across all participants in the study, and to our knowledge this is the first report of hephaestin and HIF-1α as potential markers of iron status. Further studies are needed to corroborate the findings, utilizing a broader range of markers to monitor inflammatory as well as iron status.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferritins / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Mol Biol Rep Year: 2023 Document Type: Article Affiliation country: S11033-022-08221-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ferritins / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Mol Biol Rep Year: 2023 Document Type: Article Affiliation country: S11033-022-08221-3