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COVID-19 Outcomes and Risk Factors Among People Living with HIV.
Spinelli, Matthew A; Jones, Benjamin L H; Gandhi, Monica.
  • Spinelli MA; Division of HIV, ID, and Global Medicine, University of California, San Francisco, CA, 94110, USA.
  • Jones BLH; Department of Medicine, University of California, San Francisco, CA, USA.
  • Gandhi M; Division of HIV, ID, and Global Medicine, University of California, San Francisco, CA, 94110, USA. Monica.Gandhi@UCSF.edu.
Curr HIV/AIDS Rep ; 19(5): 425-432, 2022 10.
Article in English | MEDLINE | ID: covidwho-2174983
ABSTRACT
PURPOSE OF REVIEW In this review, we examine the intersection of the HIV and COVID-19 epidemics with focus on COVID-19-related health outcomes and risk factors for SARS-CoV-2 among people living with HIV (PLWH). RECENT

FINDINGS:

Evidence to date do not suggest a higher incidence of SARS-CoV-2 infection among PLWH compared to the general population, although-once exposed-PLWH are at greater risk of severe COVID-19 outcomes. Key risk factors for severe COVID-19 include non-HIV comorbidities known to be associated with severe disease, as well as HIV-specific risk factors such as low CD4 + T-cell count, unsuppressed viral load, and tuberculosis co-infection. The disproportionate impact of the SARS-CoV-2 pandemic among Black, Latinx, and Native American/Alaskan Native PLWH could worsen pre-existing disparities in health outcomes among PLWH. Data on SARS-CoV-2 vaccine protection among PLWH needs additional study, although some studies suggest decreased humoral responses among those with low CD4 + T-cell counts, while there is a signal of increased vaccine breakthrough rates among PLWH in two large observational cohorts. Data on post-acute sequelae of SARS-CoV-2 (PASC) among PLWH is also limited. PLWH do not have a higher susceptibility to SARS-CoV-2, but once exposed, they are at higher risk of severe COVID-19 outcomes. Additional resources will need to be dedicated to the development of interventions to improve health outcomes and address disparities among PLWH impacted by the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / HIV Infections / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: AIDS Rep Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: S11904-022-00618-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / HIV Infections / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: AIDS Rep Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: S11904-022-00618-w