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The Incidence of Myocarditis Following an Influenza Vaccination: A Population-Based Observational Study.
Wang, Wen-Hwa; Wei, Kai-Che; Huang, Yu-Tung; Huang, Kuang-Hua; Tsai, Tung-Han; Chang, Yu-Chia.
  • Wang WH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Wei KC; College of Management, I-Shou University, Kaohsiung, Taiwan.
  • Huang YT; Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Huang KH; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Tsai TH; Center for Big Data Analytics and Statistics, Department of Medical Research and Development, Chang Gung Memorial Hospital Linkou Main Branch, Taoyuan, Taiwan.
  • Chang YC; Department of Health Care Management, College of Management, Chang Gung University, Taoyuan, Taiwan.
Drugs Aging ; 40(2): 145-151, 2023 02.
Article in English | MEDLINE | ID: covidwho-2175294
ABSTRACT
BACKGROUND AND

OBJECTIVE:

Recently, studies have pointed to a link between coronavirus disease 2019 vaccinations and myocarditis. Myocarditis following an influenza vaccine has been sporadically reported. However, it is not known whether this adverse event occurs among elderly individuals who have received influenza vaccines. We used a population-based database and a self-controlled case-series design to estimate the incidence of myocarditis following an influenza vaccination.

METHODS:

Data were extracted from Taiwan's National Health Insurance Research Database. The study population consisted of elderly people aged ≥ 65 years who had de novo myocarditis, which required hospitalization, within 6 months after receiving an influenza vaccination between 2003 and 2017. The first 1-7, 1-14, and 1-42 days after vaccination were defined as risk intervals, and the other periods were defined as control intervals. Poisson regression was used to calculate the incidence rate ratio for myocarditis between the risk and control periods.

RESULTS:

Within 180 days following a vaccination, 191 people were hospitalized for myocarditis among 19,678,904 people. In comparison with control intervals, the incidence rate ratios of an admission for myocarditis for days 1-7, 1-14, and 1-42 were 0.80 (95% confidence interval 0.36-1.81), 0.72 (95% confidence interval 0.39-1.32), and 0.73 (95% confidence interval 0.50-1.05), respectively. Subgroup analyses by sex, age, Charlson Comorbidity Index scores, and comorbidities did not yield significant differences in the incidence rate ratio.

CONCLUSIONS:

Regardless of the post-vaccination time and underlying baseline characteristics, the incidence risk of myocarditis is not significantly increased in the elderly following an influenza vaccination.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Myocarditis Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Asia Language: English Journal: Drugs Aging Journal subject: Geriatrics / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S40266-022-00997-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Myocarditis Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Asia Language: English Journal: Drugs Aging Journal subject: Geriatrics / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S40266-022-00997-0