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Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study.
Al-Mazedi, Maryam Salah; Rajan, Rajesh; Al-Jarallah, Mohammed; Dashti, Raja; Al Saber, Ahmad; Pan, Jiazhu; Zhanna, Kobalava D; Abdelnaby, Hassan; Aboelhassan, Wael; Almutairi, Farah; Alotaibi, Naser; Al Saleh, Mohammad; AlNasrallah, Noor; Al-Bader, Bader; Malhas, Haya; Ramadhan, Maryam; Brady, Peter A; Al-Zakwani, Ibrahim; Setiya, Parul; Abdullah, Mohammed; Alroomi, Moudhi; Tse, Gary.
  • Al-Mazedi MS; Dept. of Medical Laboratory Technology, Public Authority for Applied Education and Training, Kuwait.
  • Rajan R; Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
  • Al-Jarallah M; Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
  • Dashti R; Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait.
  • Al Saber A; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, UK.
  • Pan J; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, UK.
  • Zhanna KD; Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named After V.S. Moiseev, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.
  • Abdelnaby H; Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Department of Medicine, Division of Gastroenterology, Al Sabah Hospital, Kuwait.
  • Aboelhassan W; Department of Medicine, Division of Gastroenterology, Jaber Al Ahmed Hospital, South Surra, Kuwait.
  • Almutairi F; Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
  • Alotaibi N; Department of Medicine, Al Adan Hospital, Hadiya, Kuwait.
  • Al Saleh M; Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
  • AlNasrallah N; Department of Medicine, Al Adan Hospital, Hadiya, Kuwait.
  • Al-Bader B; Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait.
  • Malhas H; Department of Emergency Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
  • Ramadhan M; Department of Obstetrics and Gynaecology, Maternity Hospital, Shuwaikh Medical Area, Kuwait.
  • Brady PA; Department of Cardiology, Illinois Masonic Medical Center, Chicago, IL, USA.
  • Al-Zakwani I; Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman & Gulf Health Research, Muscat, Oman.
  • Setiya P; Department of Agrometeorology, College of Agriculture, G.B.Pant University of Agriculture & Technology, Pantnagar, Uttarakhand, India.
  • Abdullah M; Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait.
  • Alroomi M; Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait.
  • Tse G; Cardiovascular Analytics Group, Hong Kong, China; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Ann Med Surg (Lond) ; 82: 104748, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2176133
ABSTRACT
The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI) 15.5-40.0; p < 0.001), male sex (OR, 3.5; 95% CI 2.0-5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94-0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan-Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Ann Med Surg (Lond) Year: 2022 Document Type: Article Affiliation country: J.amsu.2022.104748

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Ann Med Surg (Lond) Year: 2022 Document Type: Article Affiliation country: J.amsu.2022.104748