[Cell senescence, a new target for respiratory viral infections: From influenza virus to SARS-CoV-2]. / La sénescence cellulaire, nouvelle cible des infections virales respiratoires : du virus influenza au SARS-CoV-2.
Bull Acad Natl Med
; 207(2): 193-198, 2023 Feb.
Article
in French
| MEDLINE | ID: covidwho-2176714
ABSTRACT
The accumulation of senescent cells in tissues is a key process of aging and age-related diseases, including lung diseases such as chronic obstructive pulmonary disease, lung fibrosis, or cancer. In recent years, the spectrum of respiratory diseases associated with cellular senescence has been broadened, in particular acute viral pulmonary infections, foremost among which is coronavirus disease 2019 (COVID19), which is particularly severe in the elderly or in subjects with comorbidities. Influenza virus infection, which strikes more severely at the extreme ages of life, is also associated with severe pulmonary senescence. Cellular senescence potentially represents an original target for attacking these diseases, although its specific mechanisms remain largely misunderstood. New anti-senescent therapeutic approaches are thus proposed during severe viral pulmonary infections, with the aim of preventing acute effects and/or, in the longer term, pulmonary sequelae.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Topics:
Long Covid
Language:
French
Journal:
Bull Acad Natl Med
Year:
2023
Document Type:
Article
Affiliation country:
J.banm.2022.11.011
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