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Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China.
Luo, Yasha; Lv, Huibin; Zhao, Shilin; Sun, Yuanxin; Liu, Chengyi; Chen, Chunke; Liang, Weiwen; Kwok, Kin-On; Teo, Qi Wen; So, Ray Ty; Lin, Yihan; Deng, Yuhong; Li, Biyun; Dai, Zixi; Zhu, Jie; Zhang, Dengwei; Fernando, Julia; Wu, Nicholas C; Tun, Hein M; Bruzzone, Roberto; Mok, Chris Kp; Mu, Xiaoping.
  • Luo Y; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China.
  • Lv H; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zhao S; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
  • Sun Y; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Liu C; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China.
  • Chen C; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
  • Liang W; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Kwok KO; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Teo QW; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA.
  • So RT; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Lin Y; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Deng Y; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China.
  • Li B; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China.
  • Dai Z; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zhu J; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zhang D; Department of Chemistry and The Swire Institute of Marine Science, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
  • Fernando J; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wu NC; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, USA; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, USA; Carle I
  • Tun HM; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public H
  • Bruzzone R; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Mok CK; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: kapunmok@cuhk.edu.hk.
  • Mu X; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. Electronic address: muxiaoping721@163.com.
Int J Infect Dis ; 127: 26-32, 2023 Feb.
Article in English | MEDLINE | ID: covidwho-2179536
ABSTRACT

OBJECTIVES:

Four seasonal coronaviruses, including human coronavirus (HCoV)-229E and HCoV-OC43, HCoV-NL63, and HCoV-HKU1 cause approximately 15-30% of common colds in adults. However, the full landscape of the immune trajectory to these viruses that covers the whole childhood period is still not well understood.

METHODS:

We evaluated the serological responses against the four seasonal coronaviruses in 1886 children aged under 18 years by using enzyme-linked immunosorbent assay. The optical density values against each HCoV were determined from each sample. Generalized additive models were constructed to determine the relationship between age and seroprevalence throughout the whole childhood period. The specific antibody levels against the four seasonal coronaviruses were also tested from the plasma samples of 485 pairs of postpartum women and their newborn babies.

RESULTS:

The immunoglobulin (Ig) G levels of the four seasonal coronaviruses in the mother and the newborn babies were highly correlated (229E r = 0.63; OC43 r = 0.65; NL63 r = 0.69; HKU1 r = 0.63). The seroprevalences in children showed a similar trajectory in that the levels of IgG in the neonates dropped significantly and reached the lowest level after the age of around 1 year (229E 1.18 years; OC43 0.97 years; NL63 1.01 years; HKU1 1.02 years) and then resurgence in the children who aged older than 1 year. Using the lowest level from the generalized additive models as our cutoff, the seroprevalences for HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 were 98.11%, 96.23%, 96.23% and 94.34% at the age of 16-18 years.

CONCLUSION:

Mothers share HCoV-specific IgGs with their newborn babies and the level of maternal IgGs waned at around 1 year after birth. The resurgence of the HCoV-specific IgGs was found thereafter with the increase in age suggesting repeated infection occurred in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / Coronavirus OC43, Human Type of study: Experimental Studies / Observational study Topics: Variants Limits: Adolescent / Adult / Child / Female / Humans / Infant / Infant, Newborn Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: J.ijid.2022.11.044

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus / Coronavirus OC43, Human Type of study: Experimental Studies / Observational study Topics: Variants Limits: Adolescent / Adult / Child / Female / Humans / Infant / Infant, Newborn Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: J.ijid.2022.11.044