Multicenter validation of Early Warning Scores for detection of clinical deterioration in COVID-19 hospitalized patients.
Med Intensiva (Engl Ed)
; 2022 Oct 19.
Article
in English
| MEDLINE | ID: covidwho-2181549
ABSTRACT
OBJECTIVE:
Investigate the predictive value of NEWS2, NEWS-C, and COVID-19 Severity Index for predicting intensive care unit (ICU) transfer in the next 24h.DESIGN:
Retrospective multicenter study.SETTING:
Two third-level hospitals in Argentina. PATIENTS All adult patients with confirmed COVID-19, admitted on general wards, excluding patients with non-intubated orders.INTERVENTIONS:
Patients were divided between those who were admitted to ICU and non-admitted. We calculated the three scores for each day of hospitalization. VARIABLES We evaluate the calibration and discrimination of the three scores for the outcome ICU admission within 24, 48h, and at hospital admission.RESULTS:
We evaluate 13,768 days of hospitalizations on general medical wards of 1318 patients. Among these, 126 (9.5%) were transferred to ICU. The AUROC of NEWS2 was 0.73 (95%CI 0.68-0.78) 24h before ICU admission, and 0.52 (95%CI 0.47-0.57) at hospital admission. The AUROC of NEWS-C was 0.73 (95%CI 0.68-0.78) and 0.52 (95%CI 0.47-0.57) respectively, and the AUROC of COVID-19 Severity Index was 0.80 (95%CI 0.77-0.84) and 0.61 (95%CI 0.58-0.66) respectively. COVID-19 Severity Index presented better calibration than NEWS2 and NEWS-C.CONCLUSION:
COVID-19 Severity index has better calibration and discrimination than NEWS2 and NEWS-C to predict ICU transfer during hospitalization.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS