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Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines.
Fraser, Rupsha; Orta-Resendiz, Aurelio; Mazein, Alexander; Dockrell, David H.
  • Fraser R; The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. Electronic address: rupsha.fraser@ed.ac.uk.
  • Orta-Resendiz A; Institut Pasteur, Université Paris Cité, HIV, Inflammation and Persistence Unit, F-75015 Paris, France.
  • Mazein A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
  • Dockrell DH; The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Trends Mol Med ; 29(4): 255-267, 2023 04.
Article in English | MEDLINE | ID: covidwho-2181694
ABSTRACT
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced immunity rapidly declines. Immune responses in respiratory tract mucosal tissues are crucial for early control of infection, and can generate long-term antigen-specific protection with prompt recall responses. However, currently approved SARS-CoV-2 vaccines are not amenable to adequate respiratory mucosal delivery, particularly in the upper airways, which could account for the high vaccine breakthrough infection rates and limited duration of vaccine-mediated protection. In view of these drawbacks, we outline a strategy that has the potential to enhance both the efficacy and durability of existing SARS-CoV-2 vaccines, by inducing robust memory responses in the upper respiratory tract (URT) mucosa.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2023 Document Type: Article