A convenient synthesis, in silico study and crystal structure of novel sulfamidophosphonates: Interaction with SARS-CoV-2
Journal of Molecular Structure
; 1275, 2023.
Article
in English
| Web of Science | ID: covidwho-2181707
ABSTRACT
A one-pot synthetic strategy was developed for the synthesis of novel sulfamidophosphonates via a three -component Kabachnik-Fields reaction of sulfanilamide, triethyl phosphite, and various aldehyde using ul-trasound irradiation. Seven organophosphorus derivatives were synthesized with high yields through this newly developed method. The target compounds were characterized by 1 H, 31 P, 13 C NMR, and IR. The molecular structure of 4a was obtained by X-ray diffraction on the monocrystal. Crystal belongs to the orthorhombic system with space groups Pbca. Insight into the binding mode of the synthesized com-pounds (ligand) into the binding sites of SARS-CoV2 (PDF code 5R80 ) was provided by docking studies, performed with the help of Maestro 9.0 docking software.(c) 2022 Elsevier B.V. All rights reserved.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Journal of Molecular Structure
Year:
2023
Document Type:
Article
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