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Spike-specific T cells are enriched in breastmilk following SARS-CoV-2 mRNA vaccination.
Armistead, Blair; Jiang, Yonghou; Carlson, Marc; Ford, Emily S; Jani, Saumya; Houck, John; Wu, Xia; Jing, Lichen; Pecor, Tiffany; Kachikis, Alisa; Yeung, Winnie; Nguyen, Tina; Coig, Rene; Minkah, Nana; Larsen, Sasha E; Coler, Rhea N; Koelle, David M; Harrington, Whitney E.
  • Armistead B; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Jiang Y; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Carlson M; Research Scientific Computing, Enterprise Analytics, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Ford ES; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Jani S; Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA.
  • Houck J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Wu X; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Jing L; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Pecor T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Kachikis A; Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, USA.
  • Yeung W; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Nguyen T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Coig R; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA.
  • Minkah N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Larsen SE; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Coler RN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Koelle DM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA; Department of
  • Harrington WE; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington, Seattle, Washington, USA; Department of Global Health, University of Washington, Seattle, Washington, USA. Electronic address: whitney.h
Mucosal Immunol ; 16(1): 39-49, 2023 02.
Article in English | MEDLINE | ID: covidwho-2181753
ABSTRACT
Human breastmilk is rich in T cells; however, their specificity and function are largely unknown. We compared the phenotype, diversity, and antigen specificity of T cells in breastmilk and peripheral blood of lactating individuals who received SARS-CoV-2 messenger RNA (mRNA) vaccination. Relative to blood, breastmilk contained higher frequencies of T effector and central memory populations that expressed mucosal-homing markers. T cell receptor sequence overlap was limited between blood and breastmilk. Overabundant breastmilk clones were observed in all individuals, were diverse, and contained complementarity-determining regions in three sequences with known epitope specificity, including to SARS-CoV-2 spike. SARS-CoV-2 spike-specific T cell receptors were more frequent in breastmilk compared to blood and expanded in breastmilk following a 3rd mRNA vaccine dose. Our observations indicate that the lactating breast contains a distinct T cell population that can be modulated by maternal vaccination with potential implications for passive infant protection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Milk, Human Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: J.mucimm.2023.01.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Milk, Human Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Infant Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: J.mucimm.2023.01.003