Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments.
Nanomedicine
; 48: 102653, 2023 02.
Article
in English
| MEDLINE | ID: covidwho-2181758
ABSTRACT
Tuberculosis (TB), historically the most significant cause of human morbidity and mortality, has returned as the top infectious disease worldwide, under circumstances worsened by the COVID-19 pandemic's devastating effects on public health. Although Mycobacterium tuberculosis, the causal agent, has been known of for more than a century, the development of tools to control it has been largely neglected. With the advancement of nanotechnology, the possibility of engineering tools at the nanoscale creates unique opportunities to exploit any molecular type. However, little attention has been paid to one of the major attributes of the pathogen, represented by the atypical coat and its abundant lipids. In this review, an overview of the lipids encountered in M. tuberculosis and interest in exploiting them for the development of TB control tools are presented. Then, the amalgamation of nanotechnology with mycobacterial lipids from both reported and future works are discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tuberculosis
/
Vaccines
/
COVID-19
/
Mycobacterium tuberculosis
Type of study:
Diagnostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Nanomedicine
Journal subject:
Biotechnology
Year:
2023
Document Type:
Article
Affiliation country:
J.nano.2023.102653
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