Virus exposure and neurodegenerative disease risk across national biobanks.
Neuron
; 111(7): 1086-1093.e2, 2023 04 05.
Article
in English
| MEDLINE | ID: covidwho-2181845
ABSTRACT
With recent findings connecting the Epstein-Barr virus to an increased risk of multiple sclerosis and growing concerns regarding the neurological impact of the coronavirus pandemic, we examined potential links between viral exposures and neurodegenerative disease risk. Using time series data from FinnGen for discovery and cross-sectional data from the UK Biobank for replication, we identified 45 viral exposures significantly associated with increased risk of neurodegenerative disease and replicated 22 of these associations. The largest effect association was between viral encephalitis exposure and Alzheimer's disease. Influenza with pneumonia was significantly associated with five of the six neurodegenerative diseases studied. We also replicated the Epstein-Barr/multiple sclerosis association. Some of these exposures were associated with an increased risk of neurodegeneration up to 15 years after infection. As vaccines are currently available for some of the associated viruses, vaccination may be a way to reduce some risk of neurodegenerative disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Neurodegenerative Diseases
/
Epstein-Barr Virus Infections
/
Alzheimer Disease
/
Multiple Sclerosis
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Neuron
Journal subject:
Neurology
Year:
2023
Document Type:
Article
Affiliation country:
J.neuron.2022.12.029
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