Research in brief

ABSTRACT

In mice and ferrets, the vaccine produced high levels of cross-reactive and subtype-specific antibodies and could protect animals against disease symptoms and death after infection with both antigenically matched and mismatched strains of influenza virus. According to the researchers, this "immunologic memory” of the original HIV infection is why people living with HIV are susceptible to prolonged inflammation, putting them at greater risk for developing cardiovascular disease and other comorbidities. The researchers isolated human immune cells in vitro and exposed them to the HIV protein Nef and then introduced a bacterial toxin to generate an immune response from the Nef-exposed cells.