Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study.
Can J Neurol Sci
; : 1-10, 2023 Jan 04.
Article
in English
| MEDLINE | ID: covidwho-2185000
ABSTRACT
BACKGROUND AND OBJECTIVES:
Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics and prevalence in pediatric patients remain unclear. The objective of this study was to describe the neurological involvement in a multinational cohort of hospitalized pediatric patients with SARS-CoV-2.METHODS:
This was a multicenter observational study of children <18 years of age with confirmed SARS-CoV-2 infection or multisystemic inflammatory syndrome (MIS-C) and laboratory evidence of SARS-CoV-2 infection in children, admitted to 15 tertiary hospitals/healthcare centers in Canada, Costa Rica, and Iran February 2020-May 2021. Descriptive statistical analyses were performed and logistic regression was used to identify factors associated with neurological involvement.RESULTS:
One-hundred forty-seven (21%) of 697 hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Headache (n = 103), encephalopathy (n = 28), and seizures (n = 30) were the most reported. Neurological signs/symptoms were significantly associated with ICU admission (OR 1.71, 95% CI 1.15-2.55; p = 0.008), satisfaction of MIS-C criteria (OR 3.71, 95% CI 2.46-5.59; p < 0.001), fever during hospitalization (OR 2.15, 95% CI 1.46-3.15; p < 0.001), and gastrointestinal involvement (OR 2.31, 95% CI 1.58-3.40; p < 0.001). Non-headache neurological manifestations were significantly associated with ICU admission (OR 1.92, 95% CI 1.08-3.42; p = 0.026), underlying neurological disorders (OR 2.98, 95% CI 1.49-5.97, p = 0.002), and a history of fever prior to hospital admission (OR 2.76, 95% CI 1.58-4.82; p < 0.001).DISCUSSION:
In this study, approximately 21% of hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Future studies should focus on pathogenesis and long-term outcomes in these children.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Can J Neurol Sci
Year:
2023
Document Type:
Article
Affiliation country:
Cjn.2022.347
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