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The potential impact of nanomedicine on COVID-19-induced thrombosis.
Russell, Peije; Esser, Lars; Hagemeyer, Christoph E; Voelcker, Nicolas H.
  • Russell P; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Esser L; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Manufacturing, Clayton, Victoria, Australia.
  • Hagemeyer CE; Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  • Voelcker NH; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Nat Nanotechnol ; 18(1): 11-22, 2023 01.
Article in English | MEDLINE | ID: covidwho-2185894
ABSTRACT
Extensive reports of pulmonary embolisms, ischaemic stroke and myocardial infarctions caused by coronavirus disease 2019 (COVID-19), as well as a significantly increased long-term risk of cardiovascular diseases in COVID-19 survivors, have highlighted severe deficiencies in our understanding of thromboinflammation and the need for new therapeutic options. Due to the complexity of the immunothrombosis pathophysiology, the efficacy of treatment with conventional anti-thrombotic medication is questioned. Thrombolytics do appear efficacious, but are hindered by severe bleeding risks, limiting their use. Nanomedicine can have profound impact in this context, protecting delicate (bio)pharmaceuticals from degradation en route and enabling delivery in a targeted and on demand manner. We provide an overview of the most promising nanocarrier systems and design strategies that may be adapted to develop nanomedicine for COVID-19-induced thromboinflammation, including dual-therapeutic approaches with antiviral and immunosuppressants. Resultant targeted and side-effect-free treatment may aid greatly in the fight against the ongoing COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Brain Ischemia / Stroke / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Nanotechnol Year: 2023 Document Type: Article Affiliation country: S41565-022-01270-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Brain Ischemia / Stroke / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Nat Nanotechnol Year: 2023 Document Type: Article Affiliation country: S41565-022-01270-6