Innate immune evasion strategies of SARS-CoV-2.
Nat Rev Microbiol
; 21(3): 178-194, 2023 03.
Article
in English
| MEDLINE | ID: covidwho-2243357
ABSTRACT
SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been associated with substantial global morbidity and mortality. Despite a tropism that is largely confined to the airways, COVID-19 is associated with multiorgan dysfunction and long-term cognitive pathologies. A major driver of this biology stems from the combined effects of virus-mediated interference with the host antiviral defences in infected cells and the sensing of pathogen-associated material by bystander cells. Such a dynamic results in delayed induction of type I and III interferons (IFN-I and IFN-III) at the site of infection, but systemic IFN-I and IFN-III priming in distal organs and barrier epithelial surfaces, respectively. In this Review, we examine the relationship between SARS-CoV-2 biology and the cellular response to infection, detailing how antagonism and dysregulation of host innate immune defences contribute to disease severity of COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferon Type I
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nat Rev Microbiol
Journal subject:
Microbiology
Year:
2023
Document Type:
Article
Affiliation country:
S41579-022-00839-1
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