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SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis.
Olivares-Gazca, Juan Carlos; Gale, Robert Peter; Sánchez-Bonilla, Daniela; Gallardo-Pérez, Moisés Manuel; Soto-Olvera, Silvia; Ruiz-Delgado, Guillermo J; Ruiz-Argüelles, Guillermo José.
  • Olivares-Gazca JC; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.
  • Gale RP; Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
  • Sánchez-Bonilla D; Haematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
  • Gallardo-Pérez MM; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.
  • Soto-Olvera S; Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
  • Ruiz-Delgado GJ; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.
  • Ruiz-Argüelles GJ; Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
Hematology ; 28(1): 2164443, 2023 Dec.
Article in English | MEDLINE | ID: covidwho-2187569
ABSTRACT
The severe adult respiratory syndrome virus type 2 (SARS-CoV-2) related acute respiratory distress syndrome (ARDS) has a strong immunological and inflammatory component; accordingly investigators are employing monoclonal antibodies to ameliorate the virus-induced cytokine storm such as antibodies against interleukin 6 (IL-6), tumor necrosis factors alpha (TNF-alpha) and CC chemokine receptor 5 (CCR5) (1). Cyclophosphamide (Cy) has proven its role in various settings including autoimmune diseases, and in the post-haploidentical stem cell transplant setting; Cy depletes cytotoxic and effector T cell populations while relatively sparing the regulatory T cells (Tregs) and could tip the balance away from the overtly pro-inflammatory setting (1). We present here the cases of three persons who were infected by the SARS-CoV-2 virus during the Cy-induced pancytopenia of an autologous hematopoietic stem cell transplantation (HSCT), aimed to down-regulate the immune response in multiple sclerosis (MS) (2). The surprisingly benign course of the COVID-19 in the three cases suggest that the Cy could have had a role in abrogating the inflammatory response in these persons.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Multiple Sclerosis Type of study: Prognostic study Topics: Variants Limits: Adult / Humans Language: English Journal: Hematology Journal subject: Hematology Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Multiple Sclerosis Type of study: Prognostic study Topics: Variants Limits: Adult / Humans Language: English Journal: Hematology Journal subject: Hematology Year: 2023 Document Type: Article