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Progression of hemolysis in a patient with hereditary spherocytosis after the second dose of COVID-19 mRNA vaccine.
Nomura, Jun; Seki, Masafumi; Abe, Syori; Kobayashi, Tadahiro; Okitsu, Yoko; Fukuhara, Noriko; Takahashi, Shinichiro; Harigae, Hideo; Kameoka, Junichi.
  • Nomura J; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
  • Seki M; Department of Infectious Diseases and Infection Control, International Medical Center, Saitama Medical University School of Medicine, Saitama, Japan.
  • Abe S; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
  • Kobayashi T; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
  • Okitsu Y; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
  • Fukuhara N; Department of Hematology, Tohoku University, Sendai-shi, Japan.
  • Takahashi S; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
  • Harigae H; Department of Hematology, Tohoku University, Sendai-shi, Japan.
  • Kameoka J; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai-shi, Japan.
Hum Vaccin Immunother ; 19(1): 2165381, 2023 12 31.
Article in English | MEDLINE | ID: covidwho-2187763
ABSTRACT
Herein, we report the case of a 22-year-old woman with hereditary spherocytosis (HS) whose condition worsened after administration of the coronavirus disease 2019 (COVID-19), mRNA vaccine 'BNT162b2 Pfizer-BioNTech.' The woman had been diagnosed with HS in 2005, and her condition remained stable until February 2021. In March 2021, she received the first dose of the above vaccine and experienced pain at the injection site. After the second dose in April 2021, she developed fever and general malaise. Investigations revealed progression of hemolysis, which improved after a few days. To the best of our knowledge, this is the first report of progression of hemolysis in a patient with HS after administration of the mRNA vaccine COVID-19, BNT162b2 'Pfizer-BioNTech.'
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Case report / Observational study Topics: Vaccines Limits: Adult / Female / Humans / Young adult Language: English Journal: Hum Vaccin Immunother Year: 2023 Document Type: Article Affiliation country: 21645515.2023.2165381

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Case report / Observational study Topics: Vaccines Limits: Adult / Female / Humans / Young adult Language: English Journal: Hum Vaccin Immunother Year: 2023 Document Type: Article Affiliation country: 21645515.2023.2165381