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Comparing Prospective Incident Severe Acute Respiratory Syndrome Coronavirus 2 Infection Rates During Successive Waves of Delta and Omicron in Johannesburg, South Africa.
Sokhela, Simiso; Bosch, Bronwyn; Hill, Andrew; Simmons, Bryony; Woods, Joana; Johnstone, Hilary; Madhi, Shabir; Qavi, Ambar; Ellis, Leah; Akpomiemie, Godspower; Bhaskar, Esther; Levi, Jacob; Falconer, Jonathan; Mirchandani, Manya; Perez Casas, Carmen; Moller, Karlien; Pilkington, Victoria; Pepperrell, Toby; Venter, Willem Daniel Francois.
  • Sokhela S; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Bosch B; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Hill A; Department of Pharmacology and Therapeutics, Liverpool University, Liverpool, United Kingdom.
  • Simmons B; LSE Health, London School of Economics and Political Science, London, United Kingdom.
  • Woods J; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Johnstone H; HJ-Clinical Trial Consultancy, George, South Africa.
  • Madhi S; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Qavi A; South Africa and African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Ellis L; School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Akpomiemie G; School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Bhaskar E; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Levi J; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Falconer J; Department of Intensive Care Medicine, Royal Free Hospital NHS Trust, London, United Kingdom.
  • Mirchandani M; Respiratory Department, Royal Brompton Hospital NHS Trust, London, United Kingdom.
  • Perez Casas C; School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • Moller K; Unitaid, Global Health Campus, Le Grand-Saconnex, Switzerland.
  • Pilkington V; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Pepperrell T; Oxford University Clinical Academic Graduate School, Oxford, United Kingdom.
  • Venter WDF; College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Open Forum Infect Dis ; 9(12): ofac587, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2190076
ABSTRACT
In high-risk individuals in Johannesburg, during the Delta coronavirus disease 2019 wave, 22% (125/561) were positive, with 33% symptomatic (2 hospitalizations; 1 death). During Omicron, 56% (232/411) were infected, with 24% symptomatic (no hospitalizations or deaths). The remarkable speed of infection of Omicron over Delta poses challenges to conventional severe acute respiratory syndrome coronavirus 2 control measures.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid