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Correlation between Survival and Elevated D-Dimer Levels, Ichikado, Apache Ii, and Sofa Scores
Critical Care Medicine ; 51(1 Supplement):217, 2023.
Article in English | EMBASE | ID: covidwho-2190552
ABSTRACT

INTRODUCTION:

Elevated D-dimer levels are common in hospitalized COVID-19 patients. We aimed to investigate the correlation between D-dimer levels and survival, as well as ICHIKADO, APACHE II, and SOFA scores. METHOD(S) Retrospective study of adult patients with COVID-19 admitted to the hospital between March 2020 and February 2022. Patients were divided into three groups according to D-dimer levels group 1 (G1) had levels less than 0.5 mg/L, group 2 (G2) had 0.5 to 3.99 mg/L and group 3 (G3) was above 4 mg/L. The primary outcome was survival to hospital discharge. Descriptive statistics, Chi-square, and Kruskal-Wallis tests were used. A p value <= 0.05 was considered statistically significant. RESULT(S) 830 patients were included in the study. 464 (55.9%) patients were men. Median age was 56 [45-66] years. There was a statistically significant association between D-dimer levels and survival rate. A total of 677 (81.6%) patients survived. 401 (89.3%), 235 (74.8%), and 41 (61.2%) patients survived in G1, G2, and G3 respectively, p < 0.001. There was also a statistically significant association between D-dimer levels and different severity scores. Median ICHIKADO scores across D-dimer levels;G1 had a median score of 140.00 [115-180]], G2 had a score of 157.50 [120-205], and G3 had a score of 200.00 [160- 245] (H (2) = 55.345, p < 0.001). APACHE II scores across the groups;G1 had a median score of 7.00 [5-11], G2 had a score of 10.50 [7-16], and G3 had a score of 12.00 [8-19] (H (2) = 76.817, p < 0.001). For SOFA scores, G1 had a median score of 2.00 [1-2], G2 had a score of 2.00 [1-3.25], and G3 had a score of 4.00 [2-6] (H(2)= 81.309, p < 0.001). CONCLUSION(S) In this cohort, elevation of D-dimer levels was associated with decreased survival rates as well as with increased ICHIKADO, APACHE II, and SOFA scores.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Critical Care Medicine Year: 2023 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Critical Care Medicine Year: 2023 Document Type: Article