Long-term clinical outcomes of patients with COVID-19 and chronic liver disease: US multicenter COLD study.
Hepatol Commun
; 7(1): e8874, 2023 01 01.
Article
in English
| MEDLINE | ID: covidwho-2190696
ABSTRACT
BACKGROUND:
COVID-19 is associated with higher morbidity and mortality in patients with chronic liver diseases (CLDs). However, our understanding of the long-term outcomes of COVID-19 in patients with CLD is limited.METHODS:
We conducted a multicenter, observational cohort study of adult patients with CLD who were diagnosed with COVID-19 before May 30, 2020, to determine long-term clinical outcomes. We used a control group of patients with CLD confirmed negative for COVID-19.RESULTS:
We followed 666 patients with CLD (median age 58 years, 52.8% male) for a median of 384 (interquartile range 31-462) days. The long-term mortality was 8.1%; with 3.6% experiencing delayed COVID-19-related mortality. Compared to a propensity-matched control group of patients with CLD without COVID-19 (n=1332), patients with CLD with COVID-19 had worse long-term survival [p<0.001; hazards ratio (HR) 1.69; 95% CI 1.19-2.41] and higher rate of hospitalization (p<0.001, HR 2.00, 1.62-2.48) over a 1-year follow-up period. Overall, 29.9% of patients reported symptoms of long-COVID-19. On multivariable analysis, female sex (p=0.05, HR 2.45, 1.01-2.11), Hispanic ethnicity (p=0.003, HR 1.94, 1.26-2.99), and severe COVID-19 requiring mechanical ventilation (p=0.028, HR 1.74, 1.06-2.86) predicted long-COVID-19. In survivors, liver-related laboratory parameters showed significant improvement after COVID-19 resolution. COVID-19 vaccine status was available for 72% (n=470) of patients with CLD and history of COVID-19, of whom, 70% (n=326) had received the COVID-19 vaccine.CONCLUSIONS:
Our large, longitudinal, multicenter study demonstrates a high burden of long-term mortality and morbidity in patients with CLD and COVID-19. Symptoms consistent with long-COVID-19 were present in 30% of patients with CLD. These results illustrate the prolonged implications of COVID-19 both for recovering patients and for health care systems.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Liver Diseases
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Hepatol Commun
Year:
2023
Document Type:
Article
Affiliation country:
01.HC9.0000897224.68874.de
Similar
MEDLINE
...
LILACS
LIS