Guillain-Barre Syndrome Associated with Sars-Cov-2 Infection in Two Pediatric Patients

ABSTRACT

BACKGROUND AND AIM: In the context of the current SARS-COV2 pandemic, multiple complications derived from infection have been described in the pediatric population;however, neurological involvement is rare. The objective is to describe two pediatric patients hospitalized during the SARS COV2 pandemic, who were admitted due to unspecified neurological symptoms, with a subsequent institutional diagnosis of Guillain Barre syndrome (GBS). METHOD(S) Description of two cases of pediatric patients with a diagnosis of SARS-COV2 infection and neurological symptoms treated at Fundacion Valle del Lili, with an inhospital diagnosis of Guillain Barre syndrome. Demographic data, clinical and pathological variables, treatment, and outcomes were collected and analyzed to describe the cases. RESULT(S) Male patients, 8 and 10 years old respectively, the first patient with no relevant history, patient # 2 with a history of asthma. Patient # 1 with respiratory symptoms associated with marked neurological symptoms, with sudden and progressive deterioration, clinical and electromyographic diagnosis of GBS managed with immunoglobulin and subsequent plasmapheresis. Patient # 2 with intense respiratory symptoms, requiring orotracheal intubation and vasoactive support, with subsequent neurological involvement, diagnosis of GBS, management with plasmapheresis. Both patients with recovery of mobility, rehabilitation and outpatient follow-up. CONCLUSION(S) In summary, these are the first reported cases of GBS associated with SARS-CoV-2 infection in Colombia and the first case report in Latin America describing atypical GBS presentation. Although neurological manifestations of SARS-CoV-2 infection are infrequent, physicians must be aware to establish early diagnostic suspicion of SARS-CoV-2 infection in children with neurological symptoms.