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Characteristics of Children with Paediatric Inflammatory Multisystem Syndrome Hospitalized in a Paediatric Intensive Care Unit during the Coronavirus Disease 2019 Pandemic
Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies, WFPICCS ; 23(11 Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2190815
ABSTRACT
BACKGROUND AND

AIM:

Coronavirus disease was thought to affect children less severely. However, a post viral immune mediated inflammatory process with an unclear pathogenesis has been reported also known as Paediatric Inflammatory Multisystem Syndrome (PIMS). Aim of this study is to describe the characteristics of a series of cases of PIMS hospitalized in a Pediatric Intensive Care Unit (PICU) in Athens, Greece. METHOD(S) Patients' files were reviewed from March 2020 until December 2021 to define PIMS cases as described by World Health Organization. RESULT(S) During the reviewed period, 25 cases of PIMS were admitted to our hospital. 8 were transferred in PICU and included in our study. Median age was 7.25 years. 6 patients were male. 1 had diabetes type I and 4 were obese. Presenting symptoms are shown in table 1. All patients showed increased levels of C-reactive protein, d-dimers, ferritin as well as anemia. 6 had lymphopenia, 4 hyponatremia and 3 hypoalbuminemia. All had negative PCR for Sars- Cov-2. 3 had respiratory failure and 1 required intubation. All showed elevated cardiac markers and 5 had reduced left ventricular ejection fraction that was eventually normalized. 3 were supported with inotropes and/or vasopressors and 1 with extracorporeal membrane oxygenation. Treatment was based on immunoglobulin (100%), glucocorticoids (100%) and/or biologic drugs (50% received interleukin [IL]-1 antagonists and 12% IL-6 receptor blockers). Mortality rate was 0%. CONCLUSION(S) Although PIMS following exposure to Sars-Cov-2 is a clinical syndrome with severe presentation, prognosis is good with appropriate and early treatment.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies, WFPICCS Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies, WFPICCS Year: 2022 Document Type: Article