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Non-Ischemic, Non-Hypoxic Myocardial Injury, and Long-Term Mortality in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study.
Li, Fajiu; Zhu, Xijie; Zhu, Ziyang; Yang, Yinjian; Tian, Zhuang; Wang, Duolao; Chen, Shi; Gao, Xiaoyan; Xu, Yalin; Zhang, Bo; Yu, Wei; Liu, Min; Xu, Xiqi; Li, Chenghong; Zhang, Shuyang.
  • Li F; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Zhu X; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • Zhu Z; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Yang Y; Department of Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • Tian Z; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • Wang D; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, Merseyside L3 5QA, United Kingdom.
  • Chen S; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Gao X; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Xu Y; Department of Geriatrics, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Zhang B; Department of Cardiology, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Yu W; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Liu M; Department of Geriatrics, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Xu X; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
  • Li C; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.
  • Zhang S; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Cardiol Discov ; 2(2): 77-82, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-2190855
ABSTRACT

Objective:

Cardiac damage is commonly reported in patients with coronavirus disease 2019 (COVID-19) but its prevalence and impact on the long-term survival of patients remain uncertain. This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.

Methods:

A single-center, retrospective cohort study was performed at the Affiliated Hospital of Jianghan University. Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27, 2019 to April 25, 2020 were collected. Demographic, clinical, laboratory, electrocardiogram, treatment data and all-cause mortality during follow-up were collected and analyzed.

Results:

Of the 766 patients with moderate to critically ill COVID-19, 86 (11.2%) died after a mean follow-up of 72.8 days. Myocardial injury occurred in 94 (12.3%) patients. The mortality rate was 64.9% (61/94) and 3.7% (25/672) in patients with and without myocardial injury, respectively. Cox regression showed that myocardial injury was an independent risk factor for mortality (hazard ratio 8.76, 95% confidence interval 4.76-16.11, P < 0.001). Of the 90 patients with myocardial injury with electrocardiogram results, sinus tachycardia was present in 29, bundle branch block in 26, low voltage in 10, and abnormal T-wave in 53.

Conclusions:

COVID-19 not only involves pneumonia but also cardiac damage. Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Cardiol Discov Year: 2022 Document Type: Article Affiliation country: CD9.0000000000000044

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Cardiol Discov Year: 2022 Document Type: Article Affiliation country: CD9.0000000000000044