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Multisystem Inflammatory Syndrome in Children in Western Countries? Decreasing Incidence as the Pandemic Progresses?: An Observational Multicenter International Cross-sectional Study.
Buonsenso, Danilo; Perramon, Aida; Català, Martí; Torres, Juan P; Camacho-Moreno, Germán; Rojas-Solano, Mariela; Ulloa-Gutierrez, Rolando; Camacho-Badilla, Kattia; Pérez-Corrales, Cristian; Cotugno, Nicola; Yamazaki-Nakashimada, Marco A; Estripeaut, Dora; Buddingh, Emilie Pauline; von Asmuth, Erik; van Rossum, Annemarie M C; Soler-Palacin, Pere; Rivière, Jacques G; Prats, Clara; Pino, Rosa; Paredes-Carmona, Fernando; Visa-Reñé, Núria; García-Salido, Alberto; Martínez-Mejias, Abel; Soriano-Arandes, Antoni.
  • Buonsenso D; From the Department of Woman and Child Health and Public Health, Fondazione Policlnico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Perramon A; Centro di Salute Globale, Università Cattolica del Sacro Cuore, Roma, Italy.
  • Català M; Department of Physics, Universitat Politècnica de Catalunya (UPC·BarcelonaTech), Barcelona, Catalonia, Spain.
  • Torres JP; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom.
  • Camacho-Moreno G; Department of Paediatrics, Division of Paediatric Infectious Diseases, Hospital Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.
  • Rojas-Solano M; Paediatric Infectious Diseases Unit, HOMI, Fundación Hospital Pediátrico la Misericordia, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Ulloa-Gutierrez R; Unidad de Vigilancia Epidemiológica.
  • Camacho-Badilla K; Servicio de Infectología.
  • Pérez-Corrales C; Servicio de Infectología.
  • Cotugno N; Laboratorio de Microbiología y División de Biología Molecular, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera," Caja Costarricense de Seguro Social, San José, Costa Rica.
  • Yamazaki-Nakashimada MA; Clinical and Research Unit of Clinical Immunology and Vaccinology, Academic Department of Paediatrics, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Estripeaut D; Instituto Nacional de Pediatría, Ciudad de México, México.
  • Buddingh EP; Servicio de Infectología, Hospital del Niño doctor José Renán Esquivel y Sistema Nacional de Investigación (SNI) de SENACYT, Ciudad de Panamá, Panamá.
  • von Asmuth E; Willem-Alexander Children's Hospital, Department of Paediatrics, Leiden University Medical Centre, Leiden.
  • van Rossum AMC; Willem-Alexander Children's Hospital, Department of Paediatrics, Leiden University Medical Centre, Leiden.
  • Soler-Palacin P; Department of Paediatrics and Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Centre, Rotterdam.
  • Rivière JG; Infection in Immunocompromised Paediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron.
  • Prats C; Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus.
  • Pino R; Infection in Immunocompromised Paediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Hospital Universitari Vall d'Hebron.
  • Paredes-Carmona F; Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus.
  • Visa-Reñé N; Department of Physics, Universitat Politècnica de Catalunya (UPC·BarcelonaTech), Barcelona, Catalonia, Spain.
  • García-Salido A; Department of Paediatrics, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, Barcelona.
  • Martínez-Mejias A; Department of Paediatrics, Arnau de Vilanova University Hospital, Lleida, Catalonia.
  • Soriano-Arandes A; Department of Paediatrics, Arnau de Vilanova University Hospital, Lleida, Catalonia.
Pediatr Infect Dis J ; 41(12): 989-993, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-2190916
ABSTRACT

BACKGROUND:

SARS-CoV-2 variations as well as immune protection after previous infections and/or vaccination may have altered the incidence of multisystemic inflammatory syndrome in children (MIS-C). We aimed to report an international time-series analysis of the incidence of MIS-C to determine if there was a shift in the regions or countries included into the study.

METHODS:

This is a multicenter, international, cross-sectional study. We collected the MIS-C incidence from the participant regions and countries for the period July 2020 to November 2021. We assessed the ratio between MIS-C cases and COVID-19 pediatric cases in children <18 years diagnosed 4 weeks earlier (average time for the temporal association observed in this disease) for the study period. We performed a binomial regression analysis for 8 participating sites [Bogotá (Colombia), Chile, Costa Rica, Lazio (Italy), Mexico DF, Panama, The Netherlands and Catalonia (Spain)].

RESULTS:

We included 904 cases of MIS-C, among a reference population of 17,906,432 children. We estimated a global significant decrease trend ratio in MIS-C cases/COVID-19 diagnosed cases in the previous month ( P < 0.001). When analyzing separately each of the sites, Chile and The Netherlands maintained a significant decrease trend ( P < 0.001), but this ratio was not statistically significant for the rest of sites.

CONCLUSIONS:

To our knowledge, this is the first international study describing a global reduction in the trend of the MIS-C incidence during the pandemic. COVID-19 vaccination and other factors possibly linked to the virus itself and/or community transmission may have played a role in preventing new MIS-C cases.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: INF.0000000000003713

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: INF.0000000000003713