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Dynamics of Humoral and Cellular Responses in Renal Transplant Recipients Receiving 3 Doses of SARS-CoV-2 mRNA Vaccine.
Arias-Cabrales, Carlos; Folgueiras, Montserrat; Faura, Anna; Eguia, Jorge; Padilla, Eduardo; Hurtado, Sara; Ribera, Laura; Echeverria-Esnal, Daniel; Pérez-Sáez, María José; Redondo-Pachón, Dolores; Burballa, Carla; Buxeda, Anna; Llinàs-Mallol, Laura; Cao, Higini; Barbosa, Francesc; Rovira, Xavier; Cima, Florencia; Pascual, Julio; Crespo, Marta.
  • Arias-Cabrales C; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Folgueiras M; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Faura A; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Eguia J; Laboratorio de Refèrencia de Catalunya SA, Barcelona, Spain.
  • Padilla E; Laboratorio de Refèrencia de Catalunya SA, Barcelona, Spain.
  • Hurtado S; Department of Nephrology, Fresenius Medical Care Sevices, Barcelona, Spain.
  • Ribera L; Department of Nephrology, Fresenius Medical Care Sevices, Barcelona, Spain.
  • Echeverria-Esnal D; Pharmacy Department, Hospital del Mar, Barcelona, Spain.
  • Pérez-Sáez MJ; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Redondo-Pachón D; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Burballa C; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Buxeda A; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Llinàs-Mallol L; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Cao H; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Barbosa F; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
  • Rovira X; Documentation Department, Hospital del Mar, Barcelona, Spain.
  • Cima F; COVID-19 Vaccination Team, Hospital del Mar, Barcelona, Spain.
  • Pascual J; Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Crespo M; Department of Nephrology, Hospital del Mar, Barcelona, Spain.
Transplantation ; 107(2): 457-465, 2023 02 01.
Article in English | MEDLINE | ID: covidwho-2191234
ABSTRACT

BACKGROUND:

The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity after 2 doses in KT.

METHODS:

We analyzed the dynamics of the humoral and cellular response by monitoring SARS-CoV-2 IgG antibodies against the Spike-protein (IgG-Spike) and QuantiFERON SARS-CoV-2 IFN-γ release assay 6 mo after the second dose (T2) and 28 d after the third dose of mRNA vaccines (T3) to KT and controls (dialysis patients and healthy individuals).

RESULTS:

At T2, the percentage of IgG-Spike+ KT and dialysis patients decreased (KT 65.8%-52.6%, hemodialysis 92.6-81.5%, and peritoneal dialysis 100%-90%), whereas 100% of healthy controls remained positive. About the cellular response, the percentage of responders decreased in all groups, especially in KT (22.4%-9.2%, P = 0.081). At T3, 92% of KT, 94%-98% of dialysis patients, and 100% of healthy controls were IgG-Spike+. In terms of antibody titers, patients and controls showed a reduction between T2 and T3 and about 80% of dialysis patients and 100% of controls achieved high titers after the third dose (>1479.5 Binding Antibody Units/mL), whereas this percentage was only 50% in KT. With respect to the cellular response, only KT displayed a significant rise after the third dose.

CONCLUSIONS:

The third dose of mRNA vaccine improves both humoral and cellular responses, but less effectively in KT compared with dialysis patients and healthy controls.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transplantation Year: 2023 Document Type: Article Affiliation country: TP.0000000000004433

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transplantation Year: 2023 Document Type: Article Affiliation country: TP.0000000000004433