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Histopathological findings of pericarditis in a patient with multisystem inflammatory syndrome in children associated with COVID-19: A case report.
Maruyama, Kazuaki; Yasuda, Kazushi; Ito, Ryoichi; Imanaka-Yoshida, Kyoko.
  • Maruyama K; Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan.
  • Yasuda K; Department of Pediatric Cardiology, Aichi Children's Health and Medical Centre, Obu, Japan.
  • Ito R; Department of Pediatric Cardiology, Aichi Children's Health and Medical Centre, Obu, Japan.
  • Imanaka-Yoshida K; Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan.
Pathol Int ; 73(2): 91-96, 2023 Feb.
Article in English | MEDLINE | ID: covidwho-2271137
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C), which is associated with the novel coronavirus disease 2019 (COVID-19), has been described as an inflammatory complication of exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It carries a risk of serious and lethal complications, including cardiogenic shock. Here, we report the pathological findings of the pericardium in a 10-year-old child with MIS-C, who developed pericarditis-induced cardiac tamponade. In the patient's pericardium, the numbers of infiltrating CD68+ macrophages; CD3+ , CD4+ , and CD8+ T cells; and myeloperoxidase+ granulocytes were increased, although the number of CD20+ B cells was not. These findings provide a clue to understanding the pathophysiology of MIS-C.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pericarditis / COVID-19 Type of study: Case report / Prognostic study Limits: Child / Humans Language: English Journal: Pathol Int Journal subject: Pathology Year: 2023 Document Type: Article Affiliation country: Pin.13304

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pericarditis / COVID-19 Type of study: Case report / Prognostic study Limits: Child / Humans Language: English Journal: Pathol Int Journal subject: Pathology Year: 2023 Document Type: Article Affiliation country: Pin.13304