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Post-COVID-19 condition at 6 months and COVID-19 vaccination in non-hospitalised children and young people.
Pinto Pereira, Snehal M; Nugawela, Manjula D; Rojas, Natalia K; Shafran, Roz; McOwat, Kelsey; Simmons, Ruth; Ford, Tamsin; Heyman, Isobel; Ladhani, Shamez N; Cheung, Emily Y; Fox-Smith, Lana; Dalrymple, Emma; Stephenson, Terence.
  • Pinto Pereira SM; UCL Great Ormond Street Institute of Child Health, London, UK snehal.pereira@ucl.ac.uk.
  • Nugawela MD; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Rojas NK; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Shafran R; UCL Great Ormond Street Institute of Child Health, London, UK.
  • McOwat K; Immunisation Department, Public Health England, London, UK.
  • Simmons R; Immunisation Department, Public Health England, London, UK.
  • Ford T; Department of Psychiatry, University of Cambridge, Cambridge, UK.
  • Heyman I; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Ladhani SN; Immunisation Department, Public Health England, London, UK.
  • Cheung EY; Paediatric Infectious Diseases Research Group, St George's University, London, UK.
  • Fox-Smith L; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Dalrymple E; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Stephenson T; UCL Great Ormond Street Institute of Child Health, London, UK.
Arch Dis Child ; 108(4): 289-295, 2023 04.
Article in English | MEDLINE | ID: covidwho-2193640
ABSTRACT

OBJECTIVES:

To describe the physical and mental health of children and young people (CYP) 6 months after infection with SARS-CoV-2 and explore whether this varies by COVID-19 vaccination.

DESIGN:

A non-hospitalised, national cohort of people aged 11-17 years old with PCR-confirmed SARS-CoV-2 infection and PCR negatives matched at study invitation, by age, sex, region and date of testing who completed questionnaires 6 months after PCR testing. The questionnaire included 21 symptoms and standardised scales (eg, EQ-5D-Y and Chalder Fatigue Scale).

RESULTS:

6407 test-positive and 6542 test-negative CYP completed the 6-month questionnaire 60.9% of test-positive vs 43.2% of test-negative CYP reported at least one symptom 6 months post-test; 27.6% of test-positive vs 15.9% of test-negative CYP reported 3+ symptoms. Common symptoms at 6 months were tiredness and shortness of breath among both test-positive and test-negative CYP; however, the prevalence of both was higher in test-positive (38.4% and 22.8%, respectively) compared with test-negative CYP (26.7% and 10.9%, respectively). 24.5% test-positive vs 17.8% test-negative CYP met the Delphi research definition of long COVID. Mental health, well-being, fatigue and health-related quality of life scores were similar among test-positive and test-negative CYP 6 months post-test. Similarly, symptomatology was similar among COVID-19-vaccinated and COVID-19-unvaccinated test-positive and test-negative CYP.

CONCLUSIONS:

Six-months post-PCR testing, CYP who tested positive for SARS-CoV-2 had similar symptoms to those who tested negative, but test-positive CYP had higher symptom prevalence. Mental health, well-being, fatigue and health-related quality of life were similar among test-positive and test-negative CYP, and symptoms at 6 months were similar in COVID-19 vaccinated and unvaccinated. TRIAL REGISTRATION NUMBER ISRCTN 34804192.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adolescent / Child / Humans / Infant Language: English Journal: Arch Dis Child Year: 2023 Document Type: Article Affiliation country: Archdischild-2022-324656

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adolescent / Child / Humans / Infant Language: English Journal: Arch Dis Child Year: 2023 Document Type: Article Affiliation country: Archdischild-2022-324656