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Pharmacokinetic interaction between verapamil and ritonavir-boosted nirmatrelvir: implications for the management of COVID-19 in patients with hypertension.
Haque, Obaid Imtiyazul; Mahar, Samantha; Hussain, Shahzad; Sloane, Peter.
  • Haque OI; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA oihaque@myamu.ac.in ohaque1@meei.harvard.edu.
  • Mahar S; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Hussain S; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.
  • Sloane P; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.
BMJ Case Rep ; 16(1)2023 Jan 13.
Article in English | MEDLINE | ID: covidwho-2193666
ABSTRACT
A woman in her 80s was brought to the emergency department for acute onset of generalised weakness, lethargy and altered mental state. The emergency medical service found her to have symptomatic bradycardia, and transcutaneous pacing was done. Medical history was notable for hypertension, hyperlipidaemia, type 2 diabetes, and a recently diagnosed SARS-CoV-2 (COVID-19) infection for which she was prescribed ritonavir-boosted nirmatrelvir (Paxlovid) two days before the presentation. On arrival at the hospital, she was found to have marked bradycardia with widened QRS, hyperglycaemia and metabolic acidosis. Transvenous pacing along with pressor support and insulin were initiated, and she was admitted to the intensive care unit. Drug interaction between ritonavir-boosted nirmatrelvir and verapamil leading to verapamil toxicity was suspected of causing her symptoms, and both drugs were withheld. She reverted to sinus rhythm on the fourth day, and the pacemaker was discontinued.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 / Hypertension Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 / Hypertension Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans Language: English Year: 2023 Document Type: Article