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Inositol Alleviates Pulmonary Fibrosis by Promoting Autophagy via Inhibiting the HIF-1α-SLUG Axis in Acute Respiratory Distress Syndrome.
Liang, Yufeng; Xu, Yingyi; Lu, Bingtai; Huang, Yuanming; Xu, Shuman; Xie, Junjie; Liu, Ming; Che, Di; Ma, Liuheyi; Tao, Jianping; Hong, Jie; Zhang, Jianhui; Situ, Xun; Ou, XinXu; Chen, Lihe; Li, Yang; Zhang, Lihong; Wu, Zhiyuan.
  • Liang Y; Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Xu Y; Department of Pediatrics, Linzhi People's Hospital, Linzhi, Tibet, China.
  • Lu B; Department of Anaesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Huang Y; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
  • Xu S; Guangzhou Institute of Pediatrics, Guangzhou. Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Xie J; Medical Management Department of Guangdong Province Hospital for Women and Children Healthcare, Guangzhou, Guangdong, China.
  • Liu M; Medical Management Department of Guangdong Province Hospital for Women and Children Healthcare, Guangzhou, Guangdong, China.
  • Che D; Maternal and Child Health Hospital of Sanshui District, Foshan, Guangdong, China.
  • Ma L; Guangzhou Institute of Pediatrics, Guangzhou. Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Tao J; Guangzhou Institute of Pediatrics, Guangzhou. Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Hong J; Guangzhou Institute of Pediatrics, Guangzhou. Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Zhang J; Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Situ X; Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Ou X; Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Chen L; Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Li Y; Department of Anaesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Zhang L; Library, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Wu Z; Department of Pediatrics, Linzhi People's Hospital, Linzhi, Tibet, China.
Oxid Med Cell Longev ; 2022: 1030238, 2022.
Article in English | MEDLINE | ID: covidwho-2194204
ABSTRACT
The effective remission of acute respiratory distress syndrome- (ARDS-) caused pulmonary fibrosis determines the recovery of lung function. Inositol can relieve lung injuries induced by ARDS. However, the mechanism of myo-inositol in the development of ARDS is unclear, which limits its use in the clinic. We explored the role and mechanism of myo-inositol in the development of ARDS by using an in vitro lipopolysaccharide- (LPS-) established alveolar epithelial cell inflammation model and an in vivo ARDS mouse model. Our results showed that inositol can alleviate the progression of pulmonary fibrosis. More significantly, we found that inositol can induce autophagy to inhibit the progression pulmonary fibrosis caused by ARDS. In order to explore the core regulators of ARDS affected by inositol, mRNA-seq sequencing was performed. Those results showed that transcription factor HIF-1α can regulate the expression of SLUG, which in turn can regulate the key gene E-Cadherin involved in cell epithelial-mesenchymal transition (EMT) as well as N-cadherin expression, and both were regulated by inositol. Our results suggest that inositol activates autophagy to inhibit EMT progression induced by the HIF-1α/SLUG signaling pathway in ARDS, and thereby alleviates pulmonary fibrosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Respiratory Distress Syndrome Type of study: Prognostic study Limits: Animals Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: 2022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Respiratory Distress Syndrome Type of study: Prognostic study Limits: Animals Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: 2022