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Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients.
Ma, Xi; Lu, Zhi-Yan; Qu, Yan-Juan; Xing, Li-Hong; Zhang, Yu; Lu, Yi-Bo; Dong, Li; Li, Hong-Jun; Li, Li; Yin, Xiao-Ping; Xu, Chuan-Jun.
  • Ma X; CT/MRI Room, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000, China.
  • Lu ZY; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province 430071, China.
  • Qu YJ; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province 430071, China.
  • Xing LH; CT/MRI Room, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000, China.
  • Zhang Y; CT/MRI Room, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000, China.
  • Lu YB; Department of Radiology, The Fourth People's Hospital of Nanning City, Nanning, Guangxi 530023, China.
  • Dong L; Department of Radiology, Baoding People's Hospital, Baoding 071000, China.
  • Li HJ; Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
  • Li L; Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
  • Yin XP; CT/MRI Room, Affiliated Hospital of Hebei University, Baoding, Hebei Province 071000, China.
  • Xu CJ; Department of Radiology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210003, China.
Int J Clin Pract ; 2022: 4763953, 2022.
Article in English | MEDLINE | ID: covidwho-2270119
ABSTRACT

Objectives:

The clinical and imaging features of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 and symptomatic COVID-19 patients.

Methods:

The clinical and chest computed tomography imaging data of 47 asymptomatic carriers and 36 symptomatic COVID-19 patients were derived. All patients underwent 4-6 CT scans over a period of 2-5 days.

Results:

The bulk of asymptomatic carriers who developed symptoms and most of the COVID-19 patients were older than 18 years of age with a decreased lymphocyte count, abnormal hepatic and renal function, and increased D-dimer and C-reactive protein. In the early stage, the pulmonary lesion involved mostly 1-2 lobes at the peripheral area in asymptomatic carriers but more than three lobes at both the central and peripheral areas in COVID-19 patients. In the progression stage, the lesion of asymptomatic carriers extended from the peripheral to the central area, and no significant difference was found in the lesion range compared with the symptomatic control group. In early improvement stage, the lesion was rapidly absorbed, and lesions were located primarily at the peripheral area in asymptomatic carriers; contrastingly, lesions were primarily located at both the central and peripheral areas in symptomatic patients. Asymptomatic carriers reflected a significantly shorter duration from disease onset to peak progression stage compared with the symptomatic.

Conclusions:

Asymptomatic carriers are a potential source of transmission and may become symptomatic COVID-19 patients despite indicating less severe pulmonary damage, earlier improvement, and better prognosis. Early isolation and intervention can eliminate such carriers as potential sources of transmission and improve their prognosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: 2022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: 2022