COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination.
Cancer Epidemiol Biomarkers Prev
; 32(6): 748-759, 2023 06 01.
Article
in English
| MEDLINE | ID: covidwho-20242353
ABSTRACT
BACKGROUND:
Studies have shown an increased risk of severe SARS-CoV-2-related (COVID-19) disease outcome and mortality for patients with cancer, but it is not well understood whether associations vary by cancer site, cancer treatment, and vaccination status.METHODS:
Using electronic health record data from an academic medical center, we identified a retrospective cohort of 260,757 individuals tested for or diagnosed with COVID-19 from March 10, 2020, to August 1, 2022. Of these, 52,019 tested positive for COVID-19 of whom 13,752 had a cancer diagnosis. We conducted Firth-corrected logistic regression to assess the association between cancer status, site, treatment, vaccination, and four COVID-19outcomes:
hospitalization, intensive care unit admission, mortality, and a composite "severe COVID" outcome.RESULTS:
Cancer diagnosis was significantly associated with higher rates of severe COVID, hospitalization, and mortality. These associations were driven by patients whose most recent initial cancer diagnosis was within the past 3 years. Chemotherapy receipt, colorectal cancer, hematologic malignancies, kidney cancer, and lung cancer were significantly associated with higher rates of worse COVID-19 outcomes. Vaccinations were significantly associated with lower rates of worse COVID-19 outcomes regardless of cancer status.CONCLUSIONS:
Patients with colorectal cancer, hematologic malignancies, kidney cancer, or lung cancer or who receive chemotherapy for treatment should be cautious because of their increased risk of worse COVID-19 outcomes, even after vaccination. IMPACT Additional COVID-19 precautions are warranted for people with certain cancer types and treatments. Significant benefit from vaccination is noted for both cancer and cancer-free patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Hematologic Neoplasms
/
COVID-19
/
Kidney Neoplasms
/
Lung Neoplasms
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Cancer Epidemiol Biomarkers Prev
Journal subject:
Biochemistry
/
Epidemiology
/
Neoplasms
Year:
2023
Document Type:
Article
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