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Changes in breast cancer staging trends among Egyptian women after COVID-19: A retrospective single-center study.
Abd El Wahab, Mostafa H; Ibrahim, Ahmed H; Gado, Omar; Bahbah, Ali M; Fadlalla, Waleed; Fakhry, Sherihan; Mamdouh, Mona M; Kamel, Mahmoud M; Moaz, Inas; Rabea, Ahmed; Helal, Amany M.
  • Abd El Wahab MH; 68792Ain Shams University, Cairo, Egypt.
  • Ibrahim AH; Baheya Charity's Women Cancer Hospital, Cairo, Egypt 1. Baheya Centre for Early Detection and Treatment of Breast Cancer, Giza, Egypt.
  • Gado O; 68792Ain Shams University, Cairo, Egypt.
  • Bahbah AM; 68792Ain Shams University, Cairo, Egypt.
  • Fadlalla W; Baheya Charity's Women Cancer Hospital, Cairo, Egypt 1. Baheya Centre for Early Detection and Treatment of Breast Cancer, Giza, Egypt.
  • Fakhry S; 68804National Cancer Institute, Cairo University, Cairo, Egypt.
  • Mamdouh MM; Baheya Charity's Women Cancer Hospital, Cairo, Egypt 1. Baheya Centre for Early Detection and Treatment of Breast Cancer, Giza, Egypt.
  • Kamel MM; Radiology Department, Cairo University, Cairo, Egypt.
  • Moaz I; Baheya Charity's Women Cancer Hospital, Cairo, Egypt 1. Baheya Centre for Early Detection and Treatment of Breast Cancer, Giza, Egypt.
  • Rabea A; 68804National Cancer Institute, Cairo University, Cairo, Egypt.
  • Helal AM; 68804National Cancer Institute, Cairo University, Cairo, Egypt.
Int J Immunopathol Pharmacol ; 37: 3946320231152835, 2023.
Article in English | MEDLINE | ID: covidwho-2194941
ABSTRACT

OBJECTIVES:

Since being declared a global pandemic, the SARS-CoV-2 virus had a significant impact on the entire globe. The pandemic has placed a heavy burden on healthcare systems worldwide, and cancer patients are particularly prone. Despite the fact that initial international reports suggest delays in breast cancer (BC) diagnosis and screening programs, the Egyptian context requires additional research on this topic. To examine whether COVID-19 has changed the pattern of disease presentation before and after the pandemic, focusing on the tumor, node, and metastasis (TNM) staging of the disease at the initial presentation.

METHODS:

This single-center, retrospective study of female BC patients initially diagnosed at Baheya Foundation was conducted during the following time frames from Jan 2019 to Jan 2020 (Pre COVID-19 cohort) and from Mar 2020 to Mar 2021 (post-COVID-19 cohort). We compared the two cohorts in terms of clinical characteristics, tumor characteristics, and the number of days from presentation to treatment. Our primary endpoint was the difference in the TNM stage of BC at the initial presentation.

RESULTS:

This analysis included 710 BC patients, 350 from the pre-COVID cohort and 360 from the post-COVID group. We detected a 27.9% increase in late-stage BC (stages III-IV) in the post-pandemic cohort compared to the pre-pandemic (60.1% vs. 47%, p < 0.001). The time from diagnosis to commencement of treatment was significantly longer (28.34 ± 18.845 vs 36.04 ± 23.641 days, p < 0.001) in the post-COVID cohort (mean difference = 7.702, 95% CI 4.54-10.85, p < 0.001). A higher percentage of patients in the post-pandemic cohort received systemic neoadjuvant therapy (p-value for Exact's test for all treatment options = 0.001).

CONCLUSIONS:

The number of patients requiring systemic neoadjuvant chemotherapy increased dramatically in the post-pandemic group with advanced stages of BC at presentation. This study highlights the need for proper management of cancer patients during any future pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: Int J Immunopathol Pharmacol Journal subject: Allergy and Immunology / Pharmacology / Pathology Year: 2023 Document Type: Article Affiliation country: 03946320231152835

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: Int J Immunopathol Pharmacol Journal subject: Allergy and Immunology / Pharmacology / Pathology Year: 2023 Document Type: Article Affiliation country: 03946320231152835