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Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database.
Abrahams, Alferso C; Noordzij, Marlies; Goffin, Eric; Sanchez, J Emilio; Franssen, Casper Fm; Vart, Priya; Jager, Kitty J; van Agteren, Madelon; Covic, Adrian; Mitra, Sandip; Basile, Carlo; Konings, Constantijn; Hemmelder, Marc H; Duivenvoorden, Raphaël; Hilbrands, Luuk B; Gansevoort, Ron T.
  • Abrahams AC; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Noordzij M; Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  • Goffin E; Department of Nephrology, Cliniques Universitaires Saint-Luc, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
  • Sanchez JE; Department of Nephrology, Hospital Universitario de Cabuenes, Asturias, Spain.
  • Franssen CF; Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  • Vart P; Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  • Jager KJ; ERA Registry, Amsterdam UMC Location University of Amsterdam, Medical Informatics, Amsterdam, The Netherlands.
  • van Agteren M; Amsterdam Public Health Research Institute, Quality of Care, Amsterdam, The Netherlands.
  • Covic A; Department of Internal Medicine, Erasmus MC Transplant Institute, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Mitra S; Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, 'Grigore T. Popa' University of Medicine, Iasi, Romania.
  • Basile C; Department of Renal Medicine, Manchester University Hospitals, Manchester Academy of Health Sciences Centre, UK.
  • Konings C; Associazione Nefrologica Gabriella Sebastio, Martina Franca, Italy.
  • Hemmelder MH; Catharina Ziekenhuis, Eindhoven, The Netherlands.
  • Duivenvoorden R; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands.
  • Hilbrands LB; CARIM School for Cardiovascular Disease, University of Maastricht, Maastricht, The Netherlands.
  • Gansevoort RT; Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
Perit Dial Int ; 43(1): 23-36, 2023 01.
Article in English | MEDLINE | ID: covidwho-2194992
ABSTRACT

BACKGROUND:

The clinical course of COVID-19 in peritoneal dialysis (PD) patients has so far only been analysed in relatively small, often single-centre case series. Therefore, we studied patient- and disease-related characteristics and outcomes of COVID-19 in a larger European cohort of PD patients.

METHODS:

We used data from the European Renal Association COVID-19 Database (ERACODA) on PD and haemodialysis (HD) patients with COVID-19 (presentation between February 2020 and April 2021). Hazard ratios (HR) for mortality at 3 months were calculated using Cox proportional-hazards regression. In addition, we examined functional and mental health status among survivors at this time point as determined by their treating physician.

RESULTS:

Of 216 PD patients with COVID-19, 80 (37%) were not hospitalised and 136 (63%) were hospitalised, of whom 19 (8.8%) were admitted to an intensive care unit. Mortality at 3 months for these subgroups was 18%, 40%, and 37%, respectively (p = 0.0031). Compared with HD patients, PD patients had higher mortality (crude HR 1.49; 95% CI 1.33-1.66), even when adjusted for patient characteristics and disease severity (adjusted HR 1.56; 95% CI 1.39-1.75). Follow-up data on 67 of 146 patients who survived COVID-19 showed functional recovery to pre-COVID-19 levels in 52 (78%) and mental recovery in 58 patients (87%) at 3 months after the COVID-19 diagnosis.

CONCLUSION:

The mortality rate in the first 3 months after presentation with COVID-19 is high, especially among PD patients who were hospitalised. PD patients with COVID-19 had a higher mortality risk than HD patients. The majority of surviving patients recovered both functionally and mentally from COVID-19 within 3 months.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peritoneal Dialysis / COVID-19 / Kidney Failure, Chronic Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Perit Dial Int Journal subject: Nephrology Year: 2023 Document Type: Article Affiliation country: 08968608221144395

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peritoneal Dialysis / COVID-19 / Kidney Failure, Chronic Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Perit Dial Int Journal subject: Nephrology Year: 2023 Document Type: Article Affiliation country: 08968608221144395