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Unintended impact of COVID-19 pandemic on the rate of catheter related nosocomial infections and incidence of multiple drug resistance pathogens in three intensive care units not allocated to COVID-19 patients in a large teaching hospital.
Zand, Farid; Vakili, Hedayatollah; Asmarian, Naeimehossadat; Masjedi, Mansoor; Sabetian, Golnar; Nikandish, Reza; Shafiee, Elham; Tabatabaei Esfehani, Azita; Azadi, Fatemeh; Sanaei Dashti, Anahita.
  • Zand F; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Vakili H; Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Asmarian N; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Masjedi M; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Sabetian G; Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Nikandish R; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Shafiee E; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Tabatabaei Esfehani A; Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Azadi F; Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Sanaei Dashti A; Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. anahitasanaei@gmail.com.
BMC Infect Dis ; 23(1): 11, 2023 Jan 06.
Article in English | MEDLINE | ID: covidwho-2196090
ABSTRACT

BACKGROUND:

The prevalence of resistant hospital infections in the intensive care unit (ICU) increases mortality and antibiotic resistance. COVID-19 pandemic may have unintended impact on nosocomial infections (NI) and the prevalence of resistant microorganism.

METHODOLOGY:

The present non-interventional study was performed by a pre and a post survey each lasting 8 months before (March-October 2019) and after (March-October 2020) the onset of COVID-19 pandemic in three ICU's, not allocated to COVID-19 patients, in Nemazee Hospital, Shiraz, Iran. The rates of the following nosocomial infections were compared at pre- and post-pandemic period ventilator associated pneumonia (VAP), central line associated blood stream infection (CLABSI), catheter-associated urinary tract infections (CAUTI) and incidence of multiple drug resistance (MDR) pathogens.

RESULTS:

Pre-pandemic and pandemic incidence of VAP was 23.5 and 17.2 cases per 1000 device-days, respectively; an absolute decrease of 27%. The main reason for the decrease in the rate of VAP during the pandemic was a significant decrease in the rate of VAP caused by Acinetobacter baumannii; from 39 to 17% in total VAP episodes. The rate of VAP associated with other microorganisms remained relatively unchanged from 14.2 cases in pre-pandemic period to 14.3 cases per 1000 MV-days during the pandemic (P = 0.801). Pre-pandemic incidence of CLABSI was 7.3 cases and, in pandemic period, was 6.5 cases per 1000 device-days (IRR = 0.88, 95% CI 0.43-1.73, P = 0.703). Pre-pandemic incidence of CAUTI was 2 and in pandemic period, was 1.4 cases per 1000 device-days (IRR = 0.70, 95% CI 0.22-1.98, P = 0.469).

CONCLUSION:

The results of the present study showed a decrease in the incidence of VAP in critically ill non-COVID-19 patients during the pandemic compared to before the pandemic, especially regarding Acinetobacter baumannii.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urinary Tract Infections / Cross Infection / Acinetobacter baumannii / Pneumonia, Ventilator-Associated / Catheter-Related Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: S12879-022-07962-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urinary Tract Infections / Cross Infection / Acinetobacter baumannii / Pneumonia, Ventilator-Associated / Catheter-Related Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: S12879-022-07962-7