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Trends in carbapenem resistance in Pre-COVID and COVID times in a tertiary care hospital in North India.
Chatterjee, Nirupama; Nirwan, Pushpa K; Srivastava, Shruti; Rati, Ruchi; Sharma, Lalit; Sharma, Priyanka; Dwivedi, Priyambada; Jaggi, Namita.
  • Chatterjee N; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Nirwan PK; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Srivastava S; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Rati R; Department of Microbiology, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Sharma L; Department of Microbiology, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Sharma P; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Dwivedi P; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India.
  • Jaggi N; Education and Research, Artemis Hospitals, Sector-51, Gurugram, Haryana, India. namita@artemishospitals.com.
Ann Clin Microbiol Antimicrob ; 22(1): 1, 2023 Jan 03.
Article in English | MEDLINE | ID: covidwho-2196305
ABSTRACT

BACKGROUND:

Carbapenem resistance is endemic in the Indian sub-continent. In this study, carbapenem resistance rates and the prevalence of different carbapenemases were determined in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa during two periods; Pre-COVID (August to October 2019) and COVID (January to February 2021) in a north-Indian tertiary care hospital.

METHODS:

Details of patient demographics and clinical condition was collated from the Hospital Information System and detection of carbapenemases NDM, OXA-48, VIM, IMP and KPC was done by Polymerase chain reaction (PCR) in 152 and 138 non-consecutive carbapenem resistant isolates during the two study periods respectively. Conjugation assay and sequencing of NDM and OXA-48 gene was done on a few selected isolates.

RESULTS:

As compared to Pre-COVID period, co-morbidities and the mortality rates were higher in patients harbouring carbapenem resistant organisms during the COVID period. The overall carbapenem resistance rate for all the four organisms increased from 23 to 41% between the two periods of study; with Pseudomonas aeruginosa and Klebsiella pneumoniae showing significant increase (p < 0.05). OXA-48, NDM and co-expression of NDM and OXA-48 were the most common genotypes detected. NDM-5 and OXA-232 were most common variants of NDM and OXA-48 family respectively during both the study periods.

CONCLUSION:

Higher rate of carbapenem resistance in COVID times could be attributed to increase in number of patients with co-morbidities. However, genetic elements of carbapenem resistance largely remained the same in the two time periods.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Anti-Bacterial Agents Type of study: Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Ann Clin Microbiol Antimicrob Journal subject: Microbiology / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S12941-022-00549-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Anti-Bacterial Agents Type of study: Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Ann Clin Microbiol Antimicrob Journal subject: Microbiology / Drug Therapy Year: 2023 Document Type: Article Affiliation country: S12941-022-00549-9