Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management.
Lipids Health Dis
; 20(1): 126, 2021 Oct 03.
Article
in English
| MEDLINE | ID: covidwho-2196306
ABSTRACT
The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been prevalent worldwide for more than a year and caused more than four million deaths. Liver injury was frequently observed in patients with COVID-19. Recently, a new definition of metabolic dysfunction associated fatty liver disease (MAFLD) was proposed by a panel of international experts, and the relationship between MAFLD and COVID-19 has been actively investigated. Several previous studies indicated that the patients with MAFLD had a higher prevalence of COVID-19 and a tendency to develop severe type of respiratory infection, and others indicated that liver injury would be exacerbated in the patients with MAFLD once infected with COVID-19. The mechanism underlying the relationship between MAFLD and COVID-19 infection has not been thoroughly investigated, and recent studies indicated that multifactorial mechanisms, such as altered host angiotensin converting enzyme 2 (ACE2) receptor expression, direct viral attack, disruption of cholangiocyte function, systemic inflammatory reaction, drug-induced liver injury, hepatic ischemic and hypoxic injury, and MAFLD-related glucose and lipid metabolic disorders, might jointly contribute to both of the adverse hepatic and respiratory outcomes. In this review, we discussed the relationship between MAFLD and COVID-19 based on current available literature, and summarized the recommendations for clinical management of MAFLD patients during the pandemic of COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chemical and Drug Induced Liver Injury
/
Non-alcoholic Fatty Liver Disease
/
SARS-CoV-2
/
COVID-19
/
Liver
/
Hypoxia
/
Anti-Inflammatory Agents
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Lipids Health Dis
Journal subject:
Biochemistry
/
Metabolism
Year:
2021
Document Type:
Article
Affiliation country:
S12944-021-01564-z
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