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Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report.
Loghman, Maryam; Rahmanian, Ehsan; Alikhani, Majid; Saffar, Hiva; Beikmohamadi Hezaveh, Sara; Nekooeian, Mohammad; Shahriarirad, Reza; Faezi, Seyedeh Tahereh.
  • Loghman M; Department of Internal Medicine, School of Medicine, Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Rahmanian E; Department of Rheumatology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. drrahmanianehsan@yahoo.com.
  • Alikhani M; Department of Internal Medicine, School of Medicine, Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Saffar H; Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Beikmohamadi Hezaveh S; Resident of Neurology, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Nekooeian M; Health and System Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Shahriarirad R; Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Faezi ST; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Med Case Rep ; 16(1): 488, 2022 Dec 27.
Article in English | MEDLINE | ID: covidwho-2196435
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 may be associated with late-onset necrotizing myositis, mimicking autoimmune inflammatory myositis; however, the exact underlying pathogenesis of severe acute respiratory syndrome coronavirus 2-induced myositis is still unclear. CASE PRESENTATION Herein, we report a rare case of necrotizing autoimmune myositis in a 67-year-old middle eastern male following coronavirus disease 2019 infection, who presented with muscle weakness. The patient had positive anti-NXP2. The diagnosis of necrotizing autoimmune myositis was made according to muscle weakness, increased liver enzymes, electromyography and nerve conduction velocity results, and muscle biopsy. The patient underwent a full malignancy evaluation, which was unremarkable, and was discharged in relatively well condition with a daily dose of 1 mg/kg prednisolone and azathioprine 150 mg (2 mg/kg).

CONCLUSION:

Our report highlights the already known possible protracted sequence of coronavirus disease 2019 infection and the potential for delayed-onset necrotizing myositis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 / Myositis Type of study: Case report / Diagnostic study / Experimental Studies Topics: Long Covid Limits: Aged / Humans / Male Language: English Journal: J Med Case Rep Year: 2022 Document Type: Article Affiliation country: S13256-022-03680-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / COVID-19 / Myositis Type of study: Case report / Diagnostic study / Experimental Studies Topics: Long Covid Limits: Aged / Humans / Male Language: English Journal: J Med Case Rep Year: 2022 Document Type: Article Affiliation country: S13256-022-03680-5