Risk factors for SARS-CoV-2 related mortality and hospitalization before vaccination: A meta-analysis.
PLOS Glob Public Health
; 2(11): e0001187, 2022.
Article
in English
| MEDLINE | ID: covidwho-2196832
ABSTRACT
The literature remains scarce regarding the varying point estimates of risk factors for COVID-19 associated mortality and hospitalization. This meta-analysis investigates risk factors for mortality and hospitalization, estimates individual risk factor contribution, and determines drivers of published estimate variances. We conducted a systematic review and meta-analysis of COVID-19 related mortality and hospitalization risk factors using PRISMA guidelines. Random effects models estimated pooled risks and meta-regression analyses estimated the impact of geographic region and study type. Studies conducted in North America and Europe were more likely to have lower effect sizes of mortality attributed to chronic kidney disease (OR 0.21, 95% CI 0.09-0.52 and OR 0.25, 95% CI 0.10-0.63, respectively). Retrospective studies were more likely to have decreased effect sizes of mortality attributed to chronic heart failure compared to prospective studies (OR 0.65, 95% CI 0.44-0.95). Studies from Europe and Asia (OR 0.42, 95% CI 0.30-0.57 and OR 0.49, 95% CI 0.28-0.84, respectively) and retrospective studies (OR 0.58, 95% CI 0.47-0.73) reported lower hospitalization risk attributed to male sex. Significant geographic population-based variation was observed in published comorbidity related mortality risks while male sex had less of an impact on hospitalization among European and Asian populations or in retrospective studies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Vaccines
Language:
English
Journal:
PLOS Glob Public Health
Year:
2022
Document Type:
Article
Affiliation country:
Journal.pgph.0001187
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