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A proteomic perspective and involvement of cytokines in SARS-CoV-2 infection.
Banu, Sarena; Nagaraj, Ramakrishnan; Idris, Mohammed M.
  • Banu S; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
  • Nagaraj R; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
  • Idris MM; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
PLoS One ; 18(1): e0279998, 2023.
Article in English | MEDLINE | ID: covidwho-2197134
ABSTRACT
Infection with the SARS-CoV-2 virus results in manifestation of several clinical observations from asymptomatic to multi-organ failure. Biochemically, the serious effects are due to what is described as cytokine storm. The initial infection region for COVID-19 is the nasopharyngeal/oropharyngeal region which is the site where samples are taken to examine the presence of virus. We have now carried out detailed proteomic analysis of the nasopharyngeal/oropharyngeal swab samples collected from normal individuals and those tested positive for SARS-CoV-2, in India, during the early days of the pandemic in 2020, by RTPCR, involving high throughput quantitative proteomics analysis. Several proteins like annexins, cytokines and histones were found differentially regulated in the host human cells following SARS-CoV-2 infection. Genes for these proteins were also observed to be differentially regulated when their expression was analyzed. Majority of the cytokine proteins were found to be up regulated in the infected individuals. Cell to Cell signaling interaction, Immune cell trafficking and inflammatory response pathways were found associated with the differentially regulated proteins based on network pathway analysis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2023 Document Type: Article Affiliation country: Journal.pone.0279998

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2023 Document Type: Article Affiliation country: Journal.pone.0279998